Modeling of Blood flow data

From:"Nandy, Partha" Subject:[NMusers] Modeling of Blood flow data Date:Tue, February 19, 2002 4:50 pm Hi, I am trying to model plasma concentration-time data for a topically administered drug. From the data it is apparent that the rate of absorption and hence the systemic exposure to the drug is dependent on the blood flow at the site of administration. The PK data was modeled using the following assumptions: 1 compartment linear kinetics with lag time. The blood flow in this case is measured by laser Doppler and the data are available at each sampling time point. The data set looks as follows: ID Time (hrs) DV (ng/ml) Flow 1 0 0 2.52 1 0.5 0 3.58 1 1 0.5 4.58 1 2 1.85 2.38 etc... Can someone help me with suggestions of incorporating the blood-flow information into the PK model? Thanks in advance for your suggestions. Warm Regards Partha Nandy Ph.D. PURDUE PHARMA L.P. One Stamford Forum Stamford, CT 06901-3431 Tel: (203) 588-8320 FAX: (203) 588-6328 E-mail: Partha.Nandy@pharma.com