Re: Rounding Error 134
From: TRANCHAND Brigitte <tranchan@lyon.fnclcc.fr>
Subject: Re: Rounding Error 134
Date: Tue, 14 Aug 2001 02:23:50 -0700 (PDT)
The rounding error 134 message is very common, and can be solved by changing
initial estimates, or OMEGA, SIGMA.
Your OMEGA and SIGMA are too constrained.
I tried this values (change for initial LAG) and it runs successful.
$THETA (0,39,200) (0,325,10000) (0,8,200) (0,105,1000) (0,2,2000) (0,1,5)
$OMEGA 5 5 5
$SIGMA 0.5 3
After a look to your data, I think that it is a 2-comp decline.
Moreover, why do you use FOCE method ? Results are fine with FO.
Hope this help
Dr Brigitte Tranchand
Lab Pharmacocinétique
Centre Léon-Bérard
69373 Lyon Cedex 8
France
Tel : 33 4 78 78 27 59
Fax : 33 4 78 78 27 58
e-mail : tranchan@lyon.fnclcc.fr