Rounding Error 134

From: Qun Jiao <Qun.Jiao@dupontpharma.com> Subject: Rounding Error 134 Date: 13 Aug 2001 15:18:17 -0400 Hi, I am the new Nonmem user. I have a problem that need your help. See the attached data set "DRUGB". The first time, I used control file "DRUGB-1.txt". A complete output ("DRUGB-1.out") comes out, even the objective function and estimated parameters did not look so good. The second time, I use the predicted parameters from DRUGB-1 (see control file DRUGB-2.txt), the run did not complete with a rounding error. DRUGB-2.out.txt Also, when I tried to use exact predicted para. number from DRUGB-1, it won't let me run through until I limit the decimal places for Theta, Omega and Sigma. I did change several parameters, but always get the same "rounding error, error 134" message. Did anybody ever encounter the same problem? Does anybody know what "error 134" means? By the way, I used "Digital Visual Fortran Optimizing Compiler Version 6.5, Copyright 2000". Thanks in advance for your help. QJ