70kg neonates

From: "Leon Aarons" <laarons@fs1.pa.man.ac.uk> Subject: 70kg neonates Date: Thu, 5 Jul 2001 11:32:33 GMT Nick encouraged me to post an issue about normalising pk data for neonates. He said he would then reply (why do I think I am being set up?) Anyway in Brian Anderson's paper, which Nick refers to, several pk parameters are adjusted to 70kg. I hesitate to use the word normalisation (and particularly not centring/centering see below for my other concerns about this) since I am not sure what is normal here. My concern about Brian's use of 70kg (and it is not a major one) is that although it allows quick comparison of neonate pk to adult pk, it does have the potential to confuse some readers when they want to compare values between studies. Per kg is widely used and achieves the same aim as per 70kg. I simply feel iit is more "legible". That is all. Now to my real concern: what is the spelling of centering/centring. As usual I consulted the Oxford English Dictionary and as usual I am more confused after doing that than before. In the extracts below you will find three different spellings of it. I particularly like centreing. Take your pick. Note that there is no ambiguity about the spelling of centre. Leon 1. The action of the verb CENTRE; placing in the centre, convergence to the centre. 1667 MILTON P.L. IX. 109 As God in Heav'n Is Center, yet extends to all, so thou [Earth] Centring receav'st from all those Orbs. a1732 ATTERBURY (J.) The visible centring of all the old prophecies in the person of Christ. 2. A placing in the centre or making central; the bringing of two or more centres into coincidence; spec. the setting of lenses so that their axes are in the same straight line. 1768 E. BUYS Dict. Terms of Art, Centering of an Optick-glass, is the grinding it so that the thickest part is exactly in the Middle. 1831 BREWSTER Optics xliii. 358 The..risk of imperfect centering, or of the axes of the three lenses not being in the same straight line. 1881 Edin. Rev. Oct. 537 Mr. Carter recommends that people should look to the centreing of their spectacles for themselves. 1883 Daily News 10 Sept. 2/1 When the ring rotates at high speed, any slight error of centring tends to injure the ring. 3. Arch. The temporary woodwork or framing, whereon any vaulted work is constructed (Gwilt). a1766 Parentalia in Entick London (1766) IV. 206 Both centering and scaffolding. 1861 SMILES Engineers II. 182 The centering upon which the arches of the bridge were built. 1879 SIR G. SCOTT Lect. Archit. II. 194 The use of continuous timber centering. 1885 RUSKIN Præterita iii, Well-made centreings..made this model..attractive. 4. attrib. and Comb., as centring motion, punch (sense 2), stone (sense 3). 1855 I. TAYLOR Restor. Belief 138 A centering-stone of that structure which in the age of the Antonines had arched over the Roman world. 1883 Knowledge 27 Apr. i, Secondary stage with centering motion [in a microscope]. 1884 F. J. BRITTEN Watch & Clockm. 148 Another spring..carrying a fine centreing punch. __________________________________________________ Leon Aarons School of Pharmacy and Pharmaceutical Sciences University of Manchester Manchester, M13 9PL, U.K. tel +44-161-275-2357 fax +44-161-275-2396 email l.aarons@man.ac.uk