RE: Rate constants

From: Vladimir Piotrovskij Date: November 28, 2000 technical Source: cognigencorp.com
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: Rate constants Date: Tue, 28 Nov 2000 09:07:33 +0100 I think the advantage of converting rate constants into respective time parameters is not only in helping to keep track of how reasonable parameters are. My experience says that rate constants usually have highly skewed distribution in a population which cannot be adequately described by log-normal distribution. I guess time parameters should have less skewness. In case of FO approximation it may have minimal impact, however FOCE estimates will be significantly affected and perhaps less biased. Best regards, Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Clinical Pharmacokinetics (ext. 5463) B-2340 Beerse Belgium Email: vpiotrov@janbe.jnj.com

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Nov 27, 2000 Mats Karlsson Rate constants
Nov 27, 2000 Nick Holford Re: Rate constants
Nov 28, 2000 Vladimir Piotrovskij RE: Rate constants
Nov 28, 2000 James Wright Re: Rate constants..are dead?
Nov 29, 2000 Dick Wixley RE: Rate constants..are dead?
Dec 11, 2000 Vladimir Piotrovskij RE: Rate constants..are dead?
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