Re: Rate constants

From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Rate constants Date: Tue, 28 Nov 2000 12:05:02 +1300 I have not been using rate constants in population analyses for a long time now. I have been using Tabs (absorption half-life), and Teq (equilibration aka "effect compartment" half lives) instead of KA and Keq (aka Keo) for the same reason Mats mentions. It is easier for my (limited) brain capacity to understand parameters which have units of time rather than 1/time. The only downside is that somewhere in the code I have to add this: IF (NEWIND.LE.1) LN2=LOG(2) ; for computational efficiency and then, for instance, to keep PREDPP ADVAN2 happy: TABS=THETA(PopTabs)*EXP(etaTabs) KA=LN2/TABS As for the suggestion that we consider the population model for Mats: MATS=THETA(PopMats)*EXP(etaMats) I think that we should be grateful that Mats is an individual and not a population :-) Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.htm