RE: Covariate Models Using Weight

From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: Covariate Models Using Weight Date: Sun, 21 Nov 1999 10:28:24 +0100 1. I would certainly prefer 51Cr-EDTA to CLCR, but the former is rather an exception in clinical practice. 2. I would also prefer measured CLCR to calculated. If we speak about calculated CLCR as a single parameter describing renal function, there is a lot of formulas, all based on relatively small number of subjects. I personally like the formula appeared in NONMEM Users Guide Part V, p.33 (the calculated parameter is called RF which stands for "renal function"): RF = WT*(1.66-0.011*AGE)/SCR 3. Applying any of the above mentioned formulas (Cockcroft-Gault including) is exactly what you suggest: "estimation of renal function/GFR by serum creatinine plus other covariates". Vladimir ---------------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Janssen Research Foundation Clinical Pharmacokinetics B-2340 Beerse Belgium Email: vpiotrov@janbe.jnj.com