Re: Standard error of 'secondary' parameters

Date: Sat, 13 Nov 1999 07:15:30 +1300 From: Nick Holford <n.holford@auckland.ac.nz> Subject: Re: Standard error of 'secondary' parameters LSheiner wrote: > CAUTION: if, in the above exampe, Cl or V in the original code have > etas attached, then this gets very very tricky if you redally beieve in the > original model. That is, the following 2 models are NOT identical: > > Cl = theta(1)+eta(1) > V = theta(2)+eta(2) > > and > > Cl = theta(1)+eta(1 > s = theta(2)+eta(2 > V = .693*Cl/s > > ESPECIALLY if a diagonal OMEGA is used. Hence they may yield different > obj fun values, parameter estimates (even for Cl), and predictions of y. Why not do this to make the models identical in the eta structure? Cl = theta(1)+eta(1 s = theta(2) V = .693*Cl/s+eta(2) -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.html