Welcome to the new small sample size world of NONMEM VI

From: Nick Holford n.holford@auckland.ac.nz Subject: [NMusers] Welcome to the new small sample size world of NONMEM VI Date: Thu, 30 Nov 2006 10:26:49 +1300 0TOT NO. OF INDIVIDUALS, 1001, IS GREATER THAN MAXIDS, 1000. INCREASE MAXIDS IN SIZES -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/

Nick, you haven't read the instructions yet, have you (typical male, try the toy without reading the instruction). First page, Introduction #5, edit the sizes file and recompile. Mark Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com

From: Nick Holford n.holford@auckland.ac.nz Subject: RE: [NMusers] Welcome to the new small sample size world of NONMEM VI Date: Fri, 01 Dec 2006 11:38:43 +1300 Mark, I haven't checked every parameter in the final release to see if they are compatible with NONMEM V defaults. But I think it very odd that NONMEM VI should by default impose restrictions that were not present in NONMEM V nor in the beta release of NONMEM VI. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/

From: Mark Sale - Next Level Solutions mark@nextlevelsolns.com Subject: RE: [NMusers] Welcome to the new small sample size world of NONMEM VI Date: Thu, 30 Nov 2006 17:10:24 -0700 Nick, You're right, the general expectation in the software world is for upward compatibility. The reason for the restriction on number of ids is the new option to sort the contributions to the OBJ before adding them, you have to store all the values in an array prior to sorting in this case an array of size 1000 by default. Whether or not to use sorting is also a option, (see page 4, #13). It was tested, at least a little. I think there would have been a way arround this if the SORT option isn't used (but not if SORT is used), but would have taken a lot more code. 1000 ids, I guess seemed generous. Wasn't in the beta because it was, I understand, one of the very last things added. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com _______________________________________________________