An open-source Pharmacometrics’s workflow in R: from exploration (xGx) to
model building (nlmixr) and diagnostics (ggPMX)
Sponsored by Novartis and co-hosted by Pharmacometrics Africa
https://www.pmxafrica.org/, NPC
Workshop target audience:
Pharmacometricians/modelers with basic knowledge on model building,
evaluation and qualification. Basic knowledge of writing, executing R
scripts is advantageous.
Workshop faculty:
Fariba Khanshan, Novartis Pharmacometrics, Cambridge, USA
Matt Fidler, Novartis Pharmacometrics, Fort Worth, USA
Irina Baltcheva, Novartis Pharmacometrics, Basel, Switzerland
Overview:
The workshop will provide a tutorial on three open–source R packages
currently under development at Novartis, supporting the pharmacometrics
workflow in exploring and modelling clinical data:
- Exploration of the data using the Exploratory Graphics (xGx) package,
available on GitHub ( https://opensource.nibr.com/xgx/).
- Population PK and PKPD modelling of the data using nlmixr (
www.nlmixr.org http://github.com/nlmixrdevelopment/nlmixr). nlmixr
builds on the ODE solving in the RxODE package, by implementing parameter
estimation algorithms like nlme, SAEM and FOCE with interaction.
- Model building and validation using ggPMX, a library of reproducible
diagnostic plots available on CRAN and on Github (https
https://github.com/ggPMXdevelopment/ggPMX://
https://github.com/ggPMXdevelopment/ggPMX
github.com/ggPMXdevelopment/ggPMX).
The combination of the three open-source R packages provides the
pharmacometrics modelling community the opportunity to reduce the learning
curve needed to become proficient on each of the different tasks using a
stepwise framework.
Fees:
$25 / R400
Click here for more info
https://wcop2020.org/wp-content/uploads/2020/01/An-open-source-Pharmacometricians-workflow-in-R-Novartis.pdf
Click here to register https://allevents.eventsair.com/wcop2020/workshop