Dear NONMEM users,
I encountered the following problem in my NONMEM fitting:
I have data from 3 dogs receiving i.v infusion of a certain drug. For each
dog I have around 15 "time-concentration" pairs.
What I am trying to do with the data is to use NONMEM to fit them and
estimate PK parameters with ADVAN3 and TRANS4.
For each PK parameter I am trying to estimate OMEGA. However I could not do
the modeling successfully unless I fix 0 for Q and V2 in OMEGA.
Why is this happening? Is it reasonable to assume 0 inter-subject variation
for Q and V2 in my case?
Thanks a lot.
variances on PK parameters
Hi Bei;
You will not be able to estimate variances with n=3. I suggest that you fit
each dog separately.
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Bei Yang
Sent: Monday, January 17, 2011 1:57 PM
To: [email protected]
Subject: [NMusers] variances on PK parameters
Dear NONMEM users,
I encountered the following problem in my NONMEM fitting:
I have data from 3 dogs receiving i.v infusion of a certain drug. For each
dog I have around 15 "time-concentration" pairs.
What I am trying to do with the data is to use NONMEM to fit them and
estimate PK parameters with ADVAN3 and TRANS4.
For each PK parameter I am trying to estimate OMEGA. However I could not do
the modeling successfully unless I fix 0 for Q and V2 in OMEGA.
Why is this happening? Is it reasonable to assume 0 inter-subject variation
for Q and V2 in my case?
Thanks a lot.