variances on PK parameters

From: Bei Yang Date: January 17, 2011 technical Source: mail-archive.com

Dear NONMEM users, I encountered the following problem in my NONMEM fitting: I have data from 3 dogs receiving i.v infusion of a certain drug. For each dog I have around 15 "time-concentration" pairs. What I am trying to do with the data is to use NONMEM to fit them and estimate PK parameters with ADVAN3 and TRANS4. For each PK parameter I am trying to estimate OMEGA. However I could not do the modeling successfully unless I fix 0 for Q and V2 in OMEGA. Why is this happening? Is it reasonable to assume 0 inter-subject variation for Q and V2 in my case? Thanks a lot.

Jan 17, 2011	Bei Yang	variances on PK parameters
Jan 17, 2011	Michael Fossler	RE: variances on PK parameters

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variances on PK parameters

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