Dear All,
I am modeling a repeated dosing study. Subjects were given twice daily doses
for 8 weeks and a number of samples were taken on the last day of dosing. There
were also sparse samples taken at weeks 2, 4, and 6. I want to use ADDL and II
for the dosing scheme. Can I lump all doses into one line or do I have to stop
the dosing record prior to each sample and re-start again? In other words, will
the following file structure work:
ID TIME AMT ADDL II DV
1 0 10 112 12 0
1 143 0 0 0 124
1 287 0 0 0 131
.
.
.
Or do I have to use the following:
ID TIME AMT ADDL II DV
1 0 10 14 12 0
1 143 0 0 0 124
1 144 10 14 12 0
1 287 0 0 0 131
.
.
.
Thank you in advance.
BP
Use of ADDL and II
Batul,
With the addition of an EVID variable, both methods should work. If you can
assume that the system is at steady-state, it may be more efficient to use
the SS data item rather than individual doses to bring the system up to the
point of the first sample.
Cheers. Brian
Brian M. Sadler, Ph.D.
Strategic PK Consulting, LLC
1209 Seabrook Avenue
Cary, North Carolina 27511
USA
<mailto:[EMAIL PROTECTED]> [EMAIL PROTECTED]
+1 (919) 523-5485 (mobile)
+1 (508) 408-0250 (fax)
Quoted reply history
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Batul Parta
Sent: Wednesday, November 12, 2008 10:36 AM
To: [email protected]
Subject: [NMusers] Use of ADDL and II
Dear All,
I am modeling a repeated dosing study. Subjects were given twice daily doses
for 8 weeks and a number of samples were taken on the last day of dosing.
There were also sparse samples taken at weeks 2, 4, and 6. I want to use
ADDL and II for the dosing scheme. Can I lump all doses into one line or do
I have to stop the dosing record prior to each sample and re-start again? In
other words, will the following file structure work:
ID TIME AMT ADDL II DV
1 0 10 112 12 0
1 143 0 0 0 124
1 287 0 0 0 131
.
.
.
Or do I have to use the following:
ID TIME AMT ADDL II DV
1 0 10 14 12 0
1 143 0 0 0 124
1 144 10 14 12 0
1 287 0 0 0 131
.
.
.
Thank you in advance.
BP
Hi Batul,
The first method should work-- I use it relatively often.
Thanks,
Bill
Quoted reply history
________________________________
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Batul Parta
Sent: Wednesday, November 12, 2008 10:36 AM
To: [email protected]
Subject: [NMusers] Use of ADDL and II
Dear All,
I am modeling a repeated dosing study. Subjects were given twice daily
doses for 8 weeks and a number of samples were taken on the last day of
dosing. There were also sparse samples taken at weeks 2, 4, and 6. I
want to use ADDL and II for the dosing scheme. Can I lump all doses into
one line or do I have to stop the dosing record prior to each sample and
re-start again? In other words, will the following file structure work:
ID TIME AMT ADDL II DV
1 0 10 112 12 0
1 143 0 0 0 124
1 287 0 0 0 131
.
.
.
Or do I have to use the following:
ID TIME AMT ADDL II DV
1 0 10 14 12 0
1 143 0 0 0 124
1 144 10 14 12 0
1 287 0 0 0 131
.
.
.
Thank you in advance.
BP
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