Hi all,
Last days I have been struggling with installation of nonmem 7.5 on my M1 Mac
on Macos Big Sur 11.3 on MacBook Pro (13-inch, M1, 2020). It is now up and
running. For those struggling with the same, below is how I got it to work for
my situation 😊.
1. I installed Xcode and command line tools
2. GNU Fortran (GCC) 11.0.0 as available on http://hpc.sourceforge.net does
not work. It gives compilation errors. It may be fixed somewhere in the future
but there are other ways (see below). It took some time to figure this out.
Thank you for troubleshooting, @Bauer, Robert<mailto:[email protected]>!
3. I therefore deleted GFortran 11 and installed Gfortran 10 for ARM using
homebrew. I first installed homebrew as instructed on https://brew.sh and then
used the command “brew install gfortran” to get the latest working version.
While I was at it, I also installed the latest Perl version.
4. I followed the instructions https://nonmem.iconplc.com/nonmem750/MACOSX/
and downloaded the different files.
5. I changed the setup75std and removed the -m64 and -march references from
Setup75std installation script
6. I changed the name of the finish_Darwin_gfortran file to finish and
placed in an empty directory where I wanted to install nonmem (in my case
$HOME/nm750), which was required as this did not succeed automatically from the
installation script.
7. I executed the “export PATH=/usr/local/gfortran/bin:$PATH” command from
the MACOS installation instructions
8. I compiled nonmem using the command “sudo /bin/bash Setup75std
$HOME/Downloads/nm750CD $HOME/nm750 gfortran”
Cheers,
Rob
---
R. ter Heine, PhD, PharmD
Hospital pharmacist - Clinical Pharmacologist
Radboud Applied Pharmacometrics & Dept. of Pharmacy
Radboudumc , Nijmegen, The Netherlands
Telephone: +31-24-36 17744
De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan
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bij de Kamer van Koophandel in het handelsregister onder nummer 80262783.
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Update installation of NONMEM7.5 on macOS Big Sur with Silicon M1 CPU
Rob:
Thanks for working this out. I will add this to the readme file in the MACOSX
folder on the nonmem FTP site.
Meanwhile, I am puzzled as to why the appropriate finish* file was not located
by the SETUP75 script.
Can you please execute the attached script on your machine:
source fintest
and let me know what result is echoed back. It should be
util/finish_Darwin_gfortran
for MACOSX. Perhaps for M1 there is a different os identification.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com
Quoted reply history
From: Heine, Rob ter <[email protected]>
Sent: Thursday, May 6, 2021 9:38 AM
To: [email protected]; Bauer, Robert <[email protected]>
Subject: [EXTERNAL] Update installation of NONMEM7.5 on macOS Big Sur with
Silicon M1 CPU
Hi all,
Last days I have been struggling with installation of nonmem 7.5 on my M1 Mac
on Macos Big Sur 11.3 on MacBook Pro (13-inch, M1, 2020). It is now up and
running. For those struggling with the same, below is how I got it to work for
my situation 😊.
1. I installed Xcode and command line tools
2. GNU Fortran (GCC) 11.0.0 as available on
http://hpc.sourceforge.net does not work. It gives
compilation errors. It may be fixed somewhere in the future but there are other
ways (see below). It took some time to figure this out. Thank you for
troubleshooting, @Bauer, Robert<mailto:[email protected]>!
3. I therefore deleted GFortran 11 and installed Gfortran 10 for ARM using
homebrew. I first installed homebrew as instructed on
https://brew.sh and then used the command “brew install
gfortran” to get the latest working version. While I was at it, I also
installed the latest Perl version.
4. I followed the instructions
https://nonmem.iconplc.com/nonmem750/MACOSX/
and downloaded the different files.
5. I changed the setup75std and removed the -m64 and -march references from
Setup75std installation script
6. I changed the name of the finish_Darwin_gfortran file to finish and
placed in an empty directory where I wanted to install nonmem (in my case
$HOME/nm750), which was required as this did not succeed automatically from the
installation script.
7. I executed the “export PATH=/usr/local/gfortran/bin:$PATH” command from
the MACOS installation instructions
8. I compiled nonmem using the command “sudo /bin/bash Setup75std
$HOME/Downloads/nm750CD $HOME/nm750 gfortran”
Cheers,
Rob
---
R. ter Heine, PhD, PharmD
Hospital pharmacist - Clinical Pharmacologist
Radboud Applied Pharmacometrics & Dept. of Pharmacy
Radboudumc , Nijmegen, The Netherlands
Telephone: +31-24-36 17744
De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan
dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze
e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de
afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail
of informatie uit deze e-mail is alleen toegestaan met voorafgaande
schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd
bij de Kamer van Koophandel in het handelsregister onder nummer 80262783.
The content of this message is intended solely for the addressee. No rights can
be derived from this message or its attachments. If you are not the intended
recipient, we kindly request you to delete the message and inform the sender.
It is strictly prohibited to disclose, copy or distribute this email or the
information inside it, without a written consent from the sender. Radboud
university medical center is registered with the Dutch Chamber of Commerce
trade register with number 80262783.