Test Installation of MPICH2 64-bit for NONMEM 7.2.0 and gfortran 4.6.3 64-bit on Windows 7 64-bit

The following is a description and output listing of an installation of MPICH2 64-bit 1.4.1p1 from Argonne National Laboratory for use with NONMEM 7.2.0 and gfortran 4.6.3 64-bit on Windows 7 64-bit (Home Premium with Service Pack 1). This implementation was installed on single dual processor systems. Additional installation instructions are necessary for networked multiple system implementations. Because this is a test procedure with an "n" of 2 (one Intel and one AMD dual processor system), any additional information that can be provided by user experience with the procedure is welcome. Please email your comments directly to [email protected]. NOTE: Administrative privileges are required for some installation steps and is recommended. 1. Download the MPICH2 64-bit installer, mpich2-1.4.1p1-win-x86-64.msi, and these test files: foce_parallel.ctl, example1.csv and mpiwini2.pnm from ftp://ftp.globomaxnm.com/Public/nonmem720/. 2. Disable or remove any 32-bit implementations of MPICH2 if previously installed but DO NOT remove the "mpi" folder of your 64-bit NONMEM installation. 3. Double-click the Windows installer file, mpich2-1.4.1p1-win-x86-64.msi, to launch the installer. The "Welcome to the MPICH2 64-bit Setup" screen will be displayed. Click "Next>" to continue. 4. The "MPICH2 64-bit Information" screen will be displayed. This screen contains information that may be helpful to the user for installation on networked systems. Click "Next>" to continue. 5. The "License Agreement" screen will be displayed. Click the "I agree" radio button and the "Next>" button to continue. 6. The "Process Manger Setup" screen will be displayed. NOTE: Administrative privileges are required to install the smpd process. The default passphrase "behappy" was accepted. Click "Next>" to continue. 7. The "Select Installation Folder" screen was displayed. The default folder, C:\Program Files\MPICH2\, was accepted. To "Install MPICH2 64-bit for yourself or for anyone who uses this computer", you must select either the "Everyone" or "Just me" radio button. Click "Next>" to continue. 8. The "Confirm Installation" screen is displayed. Click "Next>" to continue. 9. The "Installing MPICH2 64-bit" screen is displayed and a DOS window running smpd.exe is displayed. Next, a "Windows Security Alert" screen is displayed warning the user that "Windows Firewall has blocked some features of this program." and displays the following information: Name: smpd.exe Publisher: Unknown Path: C:\program files\mpich2\bin\smpd.exe Check the box for "Private networks, such as my home or work network" and click the "Allow access" button to continue. 10. The "Installation Complete" screen is displayed noting that MPICH2 64-bit has been successfully installed. Click "Close" to exit the installer. 11. Rename or delete the libfmpich2g.a file found in the C:\nm72gf64\mpi\mpi_wing\ directory (if C:\nm72gf64\ is your NONMEM 7.2.0 installation directory). 12. Copy the libfmpich2g.a file found in the C:\Program Files\MPICH2\lib\ directory to your C:\nm72gf64\mpi\mpi_wing\ directory. 13. Add C:\Program Files\MPICH2\bin to the system PATH environment variable using the Windows 7 Control Panel. 14. Open a DOS window and run the following command: "mpiexec -register". A Windows Security Alert screen is displayed warning the user that "Windows Firewall has blocked some features of this program." and displays the following information: Name: mpiexec.exe Publisher: Unknown Path: C:\program files\mpich2\bin\mpiexec.exe Check the box for "Private networks, such as my home or work network" and click the "Allow access" button to continue. 15. Complete the account (domain\user) and password information required by the "mpiexec -register" window. The command will respond with "Password encrypted into the Registry". The DOS window may now be closed. 16. A test of MPI parallelization on a dual processor system was made using the foce_parallel.ctl control file and example1.csv data file using the mpiwini2.pnm parafile (specifying two nodes). The three files were copied to the "run" directory of the NONMEM installation and run with nmfe72.bat. Output is listed below. C:\>cd nm72gf64\run C:\nm72gf64\run>nmfe72.bat foce_parallel.ctl foce_parallel.res -parafile=mpiwini2.pnm doing nmtran WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1 (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION. CREATING MUMODEL ROUTINE... 1 file(s) copied. recompiling certain components. starting wait ending wait Exiting lpreddo Finished compiling fsubs USING PARALLEL PROFILE mpiwini2.pnm MPI TRANSFER TYPE SELECTED Completed call to gfcompile.bat Starting MPI version of nonmem execution ... License Registered to: Vulcan Science Academy Expiration Date: 14 FEB 2013 Current Date: 5 SEP 2012 Days until program expires : 164 First Order Conditional Estimation with Interaction MONITORING OF SEARCH: 0ITERATION NO.: 0 OBJECTIVE VALUE: -234.362899780043 NO. OF FUNC. EVALS.: 7 CUMULATIVE NO. OF FUNC. EVALS.: 7 NPARAMETR: 2.0000E+00 2.0000E+00 2.0000E+00 2.0000E+00 1.5000E-01 1.0000E-02 1.0000E-02 1.0000E-02 1.5000E-01 1.0000E-02 1.0000E-02 1.5000E-01 1.0000E-02 1.5000E-01 6.0000E-01 PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 GRADIENT: 6.4301E+02 -9.8755E+00 8.9912E+02 -1.6932E+03 -8.7017E+01 1.0160E+01 -4.4639E+01 1.1044E+02 1.3003E+01 -6.6558E+00 -1.0328E+00 -1.2937E+02 1.4888E+02 -5.1162E+02 3.4896E+02 0ITERATION NO.: 1 OBJECTIVE VALUE: -730.535357597287 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 15 NPARAMETR: 1.7848E+00 2.0035E+00 1.7056E+00 2.6994E+00 1.5470E-01 9.9726E-03 1.0959E-02 8.1682E-03 1.4929E-01 1.0128E-02 9.8555E-03 1.5710E-01 7.7612E-03 1.7900E-01 5.3021E-01 PARAMETER: -1.3925E-02 1.0175E-01 -5.9301E-02 4.0000E-01 1.1542E-01 9.8200E-02 1.0791E-01 8.0433E-02 9.7696E-02 1.0118E-01 1.0018E-01 1.2292E-01 7.3622E-02 1.9065E-01 3.8173E-02 GRADIENT: -3.5337E+02 1.9323E+02 3.5183E+02 -3.0016E+02 -1.9471E+01 1.0237E+01 1.3120E+01 -1.1675E+01 1.6921E+01 -1.2308E+01 6.3101E+00 -7.1465E+00 5.1784E+00 3.1359E+01 3.9114E+02 0ITERATION NO.: 2 OBJECTIVE VALUE: -823.584222708180 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 23 NPARAMETR: 1.9402E+00 1.9141E+00 1.5696E+00 2.8978E+00 1.5613E-01 9.7716E-03 1.0693E-02 8.4876E-03 1.4807E-01 1.0323E-02 9.6845E-03 1.5762E-01 7.6731E-03 1.7638E-01 4.4068E-01 PARAMETER: 6.9627E-02 5.6061E-02 -1.4249E-01 4.7097E-01 1.2002E-01 9.5779E-02 1.0481E-01 8.3193E-02 9.3695E-02 1.0409E-01 9.8691E-02 1.2461E-01 7.2397E-02 1.8323E-01 -5.4311E-02 GRADIENT: -8.1794E+01 7.2399E+01 1.9259E+02 1.9568E+02 -3.4446E+00 1.5902E+00 -5.0281E+00 4.7374E+00 2.3714E+01 -4.4090E+00 -3.6553E+00 7.3377E+00 -7.1161E+00 4.0654E+01 3.2277E+02 0ITERATION NO.: 3 OBJECTIVE VALUE: -886.742361412594 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 31 NPARAMETR: 2.1281E+00 1.7719E+00 1.2864E+00 2.4287E+00 1.5741E-01 9.6139E-03 1.1180E-02 8.1016E-03 1.4128E-01 1.0541E-02 9.7322E-03 1.5563E-01 8.2635E-03 1.6286E-01 2.2965E-01 PARAMETER: 1.6209E-01 -2.1135E-02 -3.4154E-01 2.9431E-01 1.2409E-01 9.3851E-02 1.0914E-01 7.9088E-02 7.0213E-02 1.0881E-01 1.0196E-01 1.1783E-01 7.9045E-02 1.4288E-01 -3.8018E-01 GRADIENT: 7.6454E+02 -2.4192E+01 2.3454E+02 -5.4407E+02 -1.0894E+02 5.1578E+00 -3.1172E+01 5.2487E+01 2.5683E+01 -2.8911E+00 -3.8442E+00 -5.7497E+00 1.1824E+01 -1.5287E+01 2.5607E+02 0ITERATION NO.: 4 OBJECTIVE VALUE: -1045.85079680597 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 39 NPARAMETR: 1.7398E+00 1.5610E+00 7.9316E-01 2.0334E+00 1.7590E-01 9.6227E-03 1.4580E-02 4.8261E-03 1.2535E-01 1.0908E-02 9.7967E-03 1.5220E-01 8.9762E-03 1.4016E-01 5.0059E-02 PARAMETER: -3.9470E-02 -1.4795E-01 -8.2564E-01 1.1659E-01 1.7965E-01 8.8859E-02 1.3464E-01 4.4566E-02 1.0356E-02 1.1849E-01 1.1171E-01 1.0475E-01 8.8767E-02 6.7462E-02 -1.1419E+00 GRADIENT: 1.9712E+02 -5.0878E+01 1.1517E+02 -7.2292E+02 -1.3358E+00 9.9419E+00 -3.9965E+00 3.2687E+01 -1.7110E+01 -2.7392E-01 -6.0434E+00 -8.9586E+00 7.6159E+00 -9.9247E+01 -6.4552E+01 0ITERATION NO.: 5 OBJECTIVE VALUE: -1049.19737665839 NO. OF FUNC. EVALS.: 9 CUMULATIVE NO. OF FUNC. EVALS.: 48 NPARAMETR: 1.7448E+00 1.6345E+00 7.6676E-01 2.0300E+00 1.6375E-01 9.0790E-03 1.4557E-02 2.9050E-03 1.2622E-01 1.0778E-02 1.0530E-02 1.5044E-01 9.4993E-03 1.5090E-01 4.8485E-02 PARAMETER: -3.6585E-02 -1.0192E-01 -8.5953E-01 1.1492E-01 1.4385E-01 8.6895E-02 1.3933E-01 2.7804E-02 1.3923E-02 1.1644E-01 1.2109E-01 9.8678E-02 9.6340E-02 1.0428E-01 -1.1578E+00 GRADIENT: 1.9887E+02 6.7170E+01 9.4272E+01 -6.7823E+02 -1.5054E+01 5.7083E+00 -3.3489E+00 3.0066E+01 -1.9060E+01 -3.6391E+00 6.5501E+00 -5.6468E+00 1.9018E+00 -9.1078E+01 -8.0581E+01 0ITERATION NO.: 6 OBJECTIVE VALUE: -1051.45311389181 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 56 NPARAMETR: 1.7044E+00 1.5705E+00 6.8651E-01 1.9818E+00 1.2088E-01 7.7638E-03 1.4545E-02 -4.9919E-03 1.3345E-01 1.0938E-02 1.1884E-02 1.4000E-01 1.2790E-02 2.1929E-01 4.8886E-02 PARAMETER: -6.0046E-02 -1.4189E-01 -9.7024E-01 9.0865E-02 -7.9091E-03 8.6484E-02 1.6203E-01 -5.5608E-02 4.1900E-02 1.1360E-01 1.3859E-01 6.0677E-02 1.4825E-01 2.9017E-01 -1.1537E+00 GRADIENT: 1.4605E+02 -3.4141E+01 4.7505E+01 -4.9969E+02 -6.6773E+01 1.5820E+01 1.0419E+01 1.5495E+01 -1.9158E+01 -1.6050E-01 -3.4581E+00 -4.3484E+00 -7.7189E+00 -3.4158E+01 -7.0316E+01 0ITERATION NO.: 7 OBJECTIVE VALUE: -1053.28204901440 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 64 NPARAMETR: 1.7079E+00 1.5729E+00 6.5428E-01 1.9569E+00 1.3292E-01 5.5204E-03 1.3534E-02 -9.9405E-03 1.4429E-01 1.0702E-02 1.4002E-02 1.3009E-01 1.8319E-02 2.4838E-01 5.0705E-02 PARAMETER: -5.7965E-02 -1.4034E-01 -1.0184E+00 7.8197E-02 3.9545E-02 5.8644E-02 1.4377E-01 -1.0560E-01 8.2038E-02 1.1061E-01 1.5725E-01 2.4893E-02 2.2566E-01 3.4831E-01 -1.1355E+00 GRADIENT: 1.3122E+02 -2.9386E+01 3.6242E+01 -4.5848E+02 -4.2279E+01 1.1289E+01 9.0949E+00 1.1150E+01 -1.0022E+01 3.4432E-01 -2.4337E+00 -4.3078E+00 -7.3695E+00 -2.1152E+01 -5.4965E+01 0ITERATION NO.: 8 OBJECTIVE VALUE: -1058.11195761051 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 72 NPARAMETR: 1.7051E+00 1.5676E+00 6.6984E-01 1.9988E+00 1.1933E-01 -1.1990E-03 4.3193E-03 -2.1879E-02 1.5392E-01 8.1365E-03 2.1319E-02 9.5540E-02 4.1531E-02 2.5768E-01 4.7513E-02 PARAMETER: -5.9584E-02 -1.4377E-01 -9.9486E-01 9.9411E-02 -1.4389E-02 -1.3443E-02 4.8428E-02 -2.4530E-01 1.1507E-01 8.6331E-02 2.2268E-01 -1.2447E-01 5.8937E-01 3.2590E-01 -1.1680E+00 GRADIENT: 9.0466E+01 -1.7084E+01 6.6763E+01 -4.2277E+02 -5.9976E+01 5.7822E+00 1.4025E+01 6.2479E-01 -4.7634E+00 -1.9893E+00 8.6450E-01 -2.7548E+01 5.6407E+00 -2.1006E+01 -9.6275E+01 0ITERATION NO.: 9 OBJECTIVE VALUE: -1058.99697780938 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 80 NPARAMETR: 1.6880E+00 1.5658E+00 6.1963E-01 1.9934E+00 1.0946E-01 -2.7713E-03 -2.6121E-03 -2.5788E-02 1.4325E-01 6.7901E-03 2.4303E-02 9.1550E-02 5.6672E-02 2.4702E-01 5.2966E-02 PARAMETER: -6.9683E-02 -1.4490E-01 -1.0729E+00 9.6693E-02 -5.7558E-02 -3.2443E-02 -3.0579E-02 -3.0188E-01 7.8969E-02 7.3573E-02 2.5878E-01 -1.4476E-01 8.0209E-01 2.5948E-01 -1.1136E+00 GRADIENT: 4.6568E+01 -4.8968E+00 5.5454E+01 -4.3174E+02 -6.8385E+01 9.6761E+00 1.5198E+01 -3.8521E+00 -1.0273E+01 -1.9894E+00 3.4635E+00 -2.2682E+01 8.1913E+00 -3.9135E+01 -6.4924E+01 0ITERATION NO.: 10 OBJECTIVE VALUE: -1060.69501727843 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 88 NPARAMETR: 1.6825E+00 1.5662E+00 6.2156E-01 1.9972E+00 1.1001E-01 -2.8205E-03 -1.0475E-02 -2.4147E-02 1.2193E-01 5.3087E-03 2.2888E-02 1.0267E-01 7.1183E-02 2.7843E-01 5.2587E-02 PARAMETER: -7.2936E-02 -1.4462E-01 -1.0698E+00 9.8594E-02 -5.5018E-02 -3.2934E-02 -1.2231E-01 -2.8196E-01 -1.6785E-03 5.9781E-02 2.6414E-01 -9.1268E-02 9.4044E-01 3.0539E-01 -1.1172E+00 GRADIENT: 4.4927E+01 -9.2679E+00 5.0235E+01 -3.8671E+02 -6.3892E+01 1.1506E+01 5.3378E+00 -8.9777E-01 -2.4707E+01 -1.2574E+00 3.2933E+00 -2.0381E+01 8.7386E+00 -2.2116E+01 -6.9497E+01 0ITERATION NO.: 11 OBJECTIVE VALUE: -1063.78121971308 NO. OF FUNC. EVALS.: 11 CUMULATIVE NO. OF FUNC. EVALS.: 99 NPARAMETR: 1.6692E+00 1.5700E+00 6.3194E-01 2.0092E+00 1.0495E-01 -4.7493E-03 -1.1366E-02 -1.8048E-02 1.4337E-01 2.2662E-03 2.1739E-02 1.4887E-01 9.9300E-02 2.9945E-01 5.0905E-02 PARAMETER: -8.0886E-02 -1.4218E-01 -1.0532E+00 1.0459E-01 -7.8587E-02 -5.6779E-02 -1.3588E-01 -2.1577E-01 7.8888E-02 1.9171E-02 2.2895E-01 9.6187E-02 1.1138E+00 3.1841E-01 -1.1335E+00 GRADIENT: 1.8340E+01 -1.0214E+00 5.7792E+01 -3.7242E+02 -7.1840E+01 5.8009E+00 1.3187E-01 2.0639E+00 -8.8633E+00 -2.5306E+00 1.6887E+00 -1.5139E+01 9.9962E+00 -1.5454E+01 -5.6075E+01 0ITERATION NO.: 12 OBJECTIVE VALUE: -1073.45524993533 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 107 NPARAMETR: 1.7165E+00 1.5989E+00 6.8707E-01 2.0775E+00 1.1913E-01 4.1658E-03 1.8960E-02 -1.8519E-02 1.3637E-01 -7.8816E-03 1.3526E-02 3.5490E-01 2.0533E-01 3.6807E-01 4.8389E-02 PARAMETER: -5.2937E-02 -1.2394E-01 -9.6942E-01 1.3804E-01 -1.5208E-02 4.6744E-02 2.1275E-01 -2.0781E-01 5.4048E-02 -9.5854E-02 1.5900E-01 5.2975E-01 1.5554E+00 3.3923E-01 -1.1588E+00 GRADIENT: 7.6024E+01 1.8055E+01 6.7944E+01 -3.0581E+02 -6.9614E+01 8.2668E+00 7.4629E+00 -6.8455E+00 -9.7506E+00 -3.4978E+00 1.5326E+00 6.4186E+00 1.1513E+01 5.7786E+00 -1.5492E+01 0ITERATION NO.: 13 OBJECTIVE VALUE: -1078.46644155941 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 115 NPARAMETR: 1.7077E+00 1.6283E+00 6.7307E-01 2.1181E+00 1.2717E-01 1.2197E-02 3.7036E-02 1.3816E-02 1.3797E-01 -1.2691E-02 1.1890E-02 2.8988E-01 2.0374E-01 3.8790E-01 5.2412E-02 PARAMETER: -5.8086E-02 -1.0570E-01 -9.9003E-01 1.5740E-01 1.7457E-02 1.3246E-01 4.0223E-01 1.5005E-01 5.6160E-02 -1.8183E-01 1.1827E-01 4.1118E-01 1.6826E+00 3.4064E-01 -1.1189E+00 GRADIENT: 8.9287E+01 3.3071E+01 5.0504E+01 -2.3188E+02 -6.5749E+01 1.2452E+01 1.0361E+01 2.3033E+00 -9.5288E+00 -6.2048E+00 2.2485E+00 -1.9421E+01 1.7492E+01 1.0582E+01 1.9586E+00 0ITERATION NO.: 14 OBJECTIVE VALUE: -1094.85487842460 NO. OF FUNC. EVALS.: 9 CUMULATIVE NO. OF FUNC. EVALS.: 124 NPARAMETR: 1.7034E+00 1.5499E+00 7.4206E-01 2.2120E+00 1.3347E-01 -1.6010E-02 3.4026E-02 2.1630E-02 1.2298E-01 -9.9718E-03 3.6577E-02 2.4888E-01 1.3857E-01 2.7478E-01 5.7914E-02 PARAMETER: -6.0627E-02 -1.5509E-01 -8.9231E-01 2.0079E-01 4.1631E-02 -1.6972E-01 3.6071E-01 2.2930E-01 -4.9409E-03 -7.0096E-02 4.6613E-01 3.3902E-01 1.2145E+00 2.0445E-01 -1.0690E+00 GRADIENT: 9.3896E+01 -3.2389E+01 5.1659E+01 -1.8343E+02 -4.3388E+01 -9.5611E+00 2.6638E+00 1.5311E+01 -1.2331E+01 -3.9686E+00 7.5255E+00 -1.2462E+01 1.3083E+01 -4.7083E+00 1.8247E+01 0ITERATION NO.: 15 OBJECTIVE VALUE: -1108.42343618393 NO. OF FUNC. EVALS.: 10 CUMULATIVE NO. OF FUNC. EVALS.: 134 NPARAMETR: 1.7152E+00 1.5690E+00 8.1144E-01 2.2985E+00 1.4502E-01 9.4389E-03 7.2763E-03 6.6756E-03 1.5408E-01 1.0860E-02 4.2074E-02 1.9750E-01 8.1490E-02 1.8134E-01 5.8582E-02 PARAMETER: -5.3693E-02 -1.4283E-01 -8.0283E-01 2.3919E-01 8.3105E-02 9.5997E-02 7.4003E-02 6.7893E-02 1.1364E-01 1.0978E-01 4.4010E-01 2.3903E-01 7.7907E-01 6.6018E-02 -1.0632E+00 GRADIENT: 9.6444E+01 -2.4098E+01 5.6410E+01 -1.1170E+02 -2.5810E+01 5.8251E+00 -7.3312E+00 1.4465E+01 6.3096E+00 -1.7964E+00 5.1575E+00 -1.3198E+01 1.3193E+01 -2.9336E+01 2.1927E+01 0ITERATION NO.: 16 OBJECTIVE VALUE: -1108.55021801978 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 142 NPARAMETR: 1.7311E+00 1.6652E+00 8.0809E-01 2.3146E+00 1.4615E-01 -1.8741E-02 -2.1629E-03 -1.3403E-02 1.2448E-01 1.8080E-02 -1.9816E-02 1.5513E-01 4.3697E-02 1.3854E-01 6.2361E-02 PARAMETER: -4.4475E-02 -8.3292E-02 -8.0697E-01 2.4617E-01 8.6999E-02 -1.8986E-01 -2.1912E-02 -1.3579E-01 -7.4856E-04 2.1096E-01 -2.5518E-01 1.1247E-01 5.2642E-01 -8.7774E-03 -1.0320E+00 GRADIENT: 1.1892E+02 8.0336E+01 4.0781E+01 -3.9479E+01 -1.9004E+01 -9.1510E+00 -7.0925E+00 1.0427E+01 -2.0954E+00 2.6594E+00 -8.6059E+00 -1.5791E+01 1.4965E+01 -3.1407E+01 3.3864E-01 0ITERATION NO.: 17 OBJECTIVE VALUE: -1111.14594040221 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 150 NPARAMETR: 1.7303E+00 1.6446E+00 7.9875E-01 2.3084E+00 1.5003E-01 -1.7901E-02 -5.6529E-03 -1.9422E-02 1.2476E-01 -5.9436E-03 -1.8358E-02 1.5248E-01 4.0483E-02 1.3528E-01 6.2009E-02 PARAMETER: -4.4935E-02 -9.5776E-02 -8.1860E-01 2.4349E-01 1.0009E-01 -1.7900E-01 -5.6523E-02 -1.9421E-01 1.4555E-03 -7.8252E-02 -2.4447E-01 1.1051E-01 4.3693E-01 -7.9338E-03 -1.0348E+00 GRADIENT: 1.1270E+02 5.7627E+01 4.8134E+01 -5.9566E+01 -1.1156E+01 -7.0737E+00 -6.7747E+00 7.1523E+00 -1.7653E+00 -2.6738E+00 -6.6049E+00 -1.4063E+01 1.2995E+01 -2.7392E+01 1.3126E+00 0ITERATION NO.: 18 OBJECTIVE VALUE: -1114.12297353280 NO. OF FUNC. EVALS.: 10 CUMULATIVE NO. OF FUNC. EVALS.: 160 NPARAMETR: 1.7173E+00 1.6257E+00 7.8204E-01 2.2950E+00 1.5364E-01 -1.2451E-02 -1.9387E-03 -1.6138E-02 1.3250E-01 -2.2544E-03 -8.1499E-03 1.6231E-01 3.8823E-02 1.3850E-01 6.0448E-02 PARAMETER: -5.2480E-02 -1.0730E-01 -8.3978E-01 2.3763E-01 1.1199E-01 -1.2302E-01 -1.9156E-02 -1.5946E-01 3.6388E-02 -2.7534E-02 -1.0799E-01 1.4342E-01 4.2071E-01 2.2733E-02 -1.0476E+00 GRADIENT: 8.5850E+01 2.7971E+01 4.0666E+01 -8.5046E+01 -6.7330E+00 -3.4612E+00 -5.1998E+00 7.6270E+00 2.3885E+00 -1.5257E+00 -4.0297E+00 -7.8590E+00 8.6061E+00 -2.0143E+01 7.0549E+00 0ITERATION NO.: 19 OBJECTIVE VALUE: -1117.11164822932 NO. OF FUNC. EVALS.: 8 CUMULATIVE NO. OF FUNC. EVALS.: 168 NPARAMETR: 1.6969E+00 1.5937E+00 7.4827E-01 2.2980E+00 1.5707E-01 -9.7430E-03 -1.0617E-03 -2.1826E-02 1.3679E-01 -4.5094E-03 6.8712E-03 1.6941E-01 3.1754E-02 1.3947E-01 5.8428E-02 PARAMETER: -6.4411E-02 -1.2721E-01 -8.8398E-01 2.3897E-01 1.2303E-01 -9.5211E-02 -1.0375E-02 -2.1329E-01 5.3919E-02 -5.1332E-02 6.1902E-02 1.6455E-01 3.4062E-01 3.5314E-02 -1.0646E+00 GRADIENT: 5.0076E+01 -5.7939E+00 1.9781E+01 -3.2283E+01 -1.6225E-01 -9.1987E-01 -2.5360E+00 2.0533E+00 1.6288E+00 -1.7096E+00 5.7087E-01 -1.7861E+00 3.2779E+00 -1.1168E+01 2.4840E+00 0ITERATION NO.: 20 OBJECTIVE VALUE: -1117.11164822932 NO. OF FUNC. EVALS.: 16 CUMULATIVE NO. OF FUNC. EVALS.: 184 NPARAMETR: 1.6969E+00 1.5937E+00 7.4827E-01 2.2980E+00 1.5707E-01 -9.7430E-03 -1.0617E-03 -2.1826E-02 1.3679E-01 -4.5094E-03 6.8712E-03 1.6941E-01 3.1754E-02 1.3947E-01 5.8428E-02 PARAMETER: -6.4411E-02 -1.2721E-01 -8.8398E-01 2.3897E-01 1.2303E-01 -9.5211E-02 -1.0375E-02 -2.1329E-01 5.3919E-02 -5.1332E-02 6.1902E-02 1.6455E-01 3.4062E-01 3.5314E-02 -1.0646E+00 GRADIENT: 3.2947E+01 -7.2584E+00 9.2805E-01 -1.5920E+02 -1.6225E-01 -9.1987E-01 -2.5360E+00 2.0533E+00 1.6288E+00 -1.7096E+00 5.7087E-01 -1.7861E+00 3.2779E+00 -1.1168E+01 1.4210E+00 0ITERATION NO.: 21 OBJECTIVE VALUE: -1120.02614421252 NO. OF FUNC. EVALS.: 14 CUMULATIVE NO. OF FUNC. EVALS.: 198 NPARAMETR: 1.6955E+00 1.6010E+00 8.1589E-01 2.3741E+00 1.6332E-01 -4.5545E-03 1.1908E-02 -8.4284E-03 1.3446E-01 3.1278E-03 8.6504E-03 1.8182E-01 1.8430E-02 1.2721E-01 5.7952E-02 PARAMETER: -6.5231E-02 -1.2266E-01 -7.9735E-01 2.7157E-01 1.4253E-01 -4.3649E-02 1.1413E-01 -8.0775E-02 4.7052E-02 3.9086E-02 9.5067E-02 1.9773E-01 1.9514E-01 1.1899E-02 -1.0687E+00 GRADIENT: 2.0764E+01 -9.5790E+00 5.4742E+00 -4.2527E+01 -1.0795E+00 -1.1726E+00 -6.9395E-01 5.6478E+00 2.2827E+00 -1.7766E+00 -4.1735E-01 3.4484E+00 -2.4423E+00 -1.0171E+01 -2.4770E+00 0ITERATION NO.: 22 OBJECTIVE VALUE: -1120.62591773424 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 211 NPARAMETR: 1.6970E+00 1.6000E+00 8.2980E-01 2.3893E+00 1.6442E-01 -1.6075E-03 9.1630E-03 -1.8853E-02 1.3169E-01 2.3889E-02 1.7662E-02 1.7496E-01 2.5014E-02 1.3771E-01 5.8511E-02 PARAMETER: -6.4367E-02 -1.2325E-01 -7.8042E-01 2.7792E-01 1.4589E-01 -1.5354E-02 8.7520E-02 -1.8007E-01 3.7079E-02 2.7360E-01 1.9943E-01 1.6700E-01 2.4456E-01 3.4961E-02 -1.0639E+00 GRADIENT: 2.0739E+01 -1.5469E+01 3.9566E+00 -9.0456E+00 7.2744E-01 -1.3306E-01 1.1272E+00 -2.4012E+00 1.3716E+00 6.4542E-01 1.2064E+00 -2.2668E+00 6.8170E-01 -6.3659E+00 -5.5405E-01 0ITERATION NO.: 23 OBJECTIVE VALUE: -1120.94124640876 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 224 NPARAMETR: 1.6870E+00 1.6069E+00 8.2016E-01 2.3877E+00 1.6574E-01 1.0122E-03 1.1894E-02 -1.2916E-02 1.3157E-01 2.0369E-02 1.5379E-02 1.8524E-01 3.1232E-02 1.4342E-01 5.7891E-02 PARAMETER: -7.0278E-02 -1.1894E-01 -7.9212E-01 2.7728E-01 1.4990E-01 9.6298E-03 1.1315E-01 -1.2288E-01 3.6639E-02 2.3169E-01 1.7646E-01 1.9881E-01 3.0826E-01 5.5850E-02 -1.0692E+00 GRADIENT: 6.9978E-01 -5.8828E+00 1.1585E-01 -9.8831E+00 7.4886E-01 9.4893E-01 -3.1640E-02 3.7153E-01 5.1912E-01 4.7916E-01 3.7479E-01 -8.6079E-02 4.3040E-01 -4.1014E+00 2.6401E+00 0ITERATION NO.: 24 OBJECTIVE VALUE: -1121.00001243846 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 237 NPARAMETR: 1.6857E+00 1.6112E+00 8.2155E-01 2.3884E+00 1.6583E-01 4.4405E-04 1.2329E-02 -1.2677E-02 1.3061E-01 1.8071E-02 1.3409E-02 1.8503E-01 2.9628E-02 1.4638E-01 5.7525E-02 PARAMETER: -7.1032E-02 -1.1631E-01 -7.9042E-01 2.7757E-01 1.5017E-01 4.2233E-03 1.1726E-01 -1.2057E-01 3.2998E-02 2.0665E-01 1.5401E-01 1.9982E-01 2.9699E-01 6.9583E-02 -1.0724E+00 GRADIENT: -2.5796E+00 -2.4580E-02 1.6123E+00 -1.1084E+01 5.7440E-01 6.3413E-01 1.4196E-01 2.5121E-01 -1.3817E-01 2.0910E-01 -2.3833E-01 5.7427E-01 -5.7648E-01 -6.0107E-01 5.8203E-01 0ITERATION NO.: 25 OBJECTIVE VALUE: -1121.02268069660 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 250 NPARAMETR: 1.6856E+00 1.6111E+00 8.1914E-01 2.3928E+00 1.6537E-01 -3.2734E-04 1.3260E-02 -1.1966E-02 1.3047E-01 1.5217E-02 1.3647E-02 1.8898E-01 3.3800E-02 1.4978E-01 5.7164E-02 PARAMETER: -7.1142E-02 -1.1633E-01 -7.9337E-01 2.7940E-01 1.4876E-01 -3.1176E-03 1.2629E-01 -1.1397E-01 3.2486E-02 1.7473E-01 1.5616E-01 2.1211E-01 3.3886E-01 7.7025E-02 -1.0755E+00 GRADIENT: -2.7473E+00 -3.8132E-01 -4.3145E-01 1.7194E+00 3.3280E-03 2.3259E-01 5.3893E-02 2.6055E-01 -6.2564E-01 -1.0960E-01 -4.9059E-03 2.0988E-01 -1.7795E-02 -2.6672E-01 4.2885E-01 0ITERATION NO.: 26 OBJECTIVE VALUE: -1121.02781376574 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 263 NPARAMETR: 1.6865E+00 1.6113E+00 8.1936E-01 2.3920E+00 1.6517E-01 -5.9070E-04 1.2680E-02 -1.2627E-02 1.3115E-01 1.5804E-02 1.3728E-02 1.8780E-01 3.3313E-02 1.4978E-01 5.7166E-02 PARAMETER: -7.0593E-02 -1.1622E-01 -7.9310E-01 2.7907E-01 1.4816E-01 -5.6293E-03 1.2084E-01 -1.2033E-01 3.5061E-02 1.8121E-01 1.5643E-01 2.0882E-01 3.3446E-01 7.7210E-02 -1.0755E+00 GRADIENT: -8.4442E-01 -4.6364E-02 -1.1723E-01 6.0036E-02 1.6025E-02 9.0250E-02 5.2026E-02 8.6292E-03 -1.7385E-01 -1.0171E-02 -4.2073E-02 3.0733E-02 -1.6361E-03 -8.8110E-02 6.0973E-02 0ITERATION NO.: 27 OBJECTIVE VALUE: -1121.02824436187 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 276 NPARAMETR: 1.6869E+00 1.6113E+00 8.1964E-01 2.3920E+00 1.6507E-01 -7.2608E-04 1.2489E-02 -1.2745E-02 1.3142E-01 1.5948E-02 1.3882E-02 1.8754E-01 3.3247E-02 1.4987E-01 5.7162E-02 PARAMETER: -7.0372E-02 -1.1622E-01 -7.9276E-01 2.7908E-01 1.4786E-01 -6.9214E-03 1.1906E-01 -1.2149E-01 3.6082E-02 1.8278E-01 1.5791E-01 2.0808E-01 3.3366E-01 7.7476E-02 -1.0755E+00 GRADIENT: -1.2461E-01 -3.3184E-02 -4.9986E-03 1.3630E-03 -1.7913E-02 4.7712E-03 2.8226E-02 -2.5417E-02 -4.2505E-03 3.0193E-03 -1.2334E-02 -2.3375E-02 1.9884E-03 -2.2988E-02 -3.7575E-02 0ITERATION NO.: 28 OBJECTIVE VALUE: -1121.02825700906 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 289 NPARAMETR: 1.6869E+00 1.6113E+00 8.1970E-01 2.3921E+00 1.6507E-01 -7.2719E-04 1.2467E-02 -1.2723E-02 1.3144E-01 1.5955E-02 1.3917E-02 1.8760E-01 3.3293E-02 1.4993E-01 5.7161E-02 PARAMETER: -7.0337E-02 -1.1620E-01 -7.9269E-01 2.7909E-01 1.4788E-01 -6.9319E-03 1.1884E-01 -1.2128E-01 3.6164E-02 1.8284E-01 1.5830E-01 2.0825E-01 3.3399E-01 7.7611E-02 -1.0755E+00 GRADIENT: -3.4875E-02 8.2778E-03 -8.4463E-04 6.3022E-04 -9.3698E-03 -1.0575E-03 1.1282E-02 -1.2183E-02 6.5938E-03 7.8327E-04 -2.4542E-03 -1.1127E-02 1.9226E-03 -6.1208E-03 -1.0356E-02 0ITERATION NO.: 29 OBJECTIVE VALUE: -1121.02825736565 NO. OF FUNC. EVALS.: 13 CUMULATIVE NO. OF FUNC. EVALS.: 302 NPARAMETR: 1.6869E+00 1.6114E+00 8.1972E-01 2.3921E+00 1.6508E-01 -7.2367E-04 1.2461E-02 -1.2710E-02 1.3143E-01 1.5957E-02 1.3926E-02 1.8763E-01 3.3308E-02 1.4994E-01 5.7161E-02 PARAMETER: -7.0329E-02 -1.1619E-01 -7.9266E-01 2.7910E-01 1.4790E-01 -6.8982E-03 1.1878E-01 -1.2116E-01 3.6152E-02 1.8286E-01 1.5841E-01 2.0833E-01 3.3409E-01 7.7643E-02 -1.0755E+00 GRADIENT: -1.6096E-02 1.2148E-02 6.0813E-04 -1.0798E-03 -3.8689E-03 -9.4392E-04 4.6329E-03 -4.9019E-03 4.1872E-03 -2.2558E-04 2.2135E-04 -4.1954E-03 7.5806E-04 -2.7540E-03 -1.4399E-03 0ITERATION NO.: 30 OBJECTIVE VALUE: -1121.02825736565 NO. OF FUNC. EVALS.: 10 CUMULATIVE NO. OF FUNC. EVALS.: 312 NPARAMETR: 1.6869E+00 1.6114E+00 8.1972E-01 2.3921E+00 1.6508E-01 -7.2367E-04 1.2461E-02 -1.2710E-02 1.3143E-01 1.5957E-02 1.3926E-02 1.8763E-01 3.3308E-02 1.4994E-01 5.7161E-02 PARAMETER: -7.0329E-02 -1.1619E-01 -7.9266E-01 2.7910E-01 1.4790E-01 -6.8982E-03 1.1878E-01 -1.2116E-01 3.6152E-02 1.8286E-01 1.5841E-01 2.0833E-01 3.3409E-01 7.7643E-02 -1.0755E+00 GRADIENT: -1.6096E-02 1.2148E-02 6.0813E-04 -1.0798E-03 -3.8689E-03 -9.4392E-04 4.6329E-03 -4.9019E-03 4.1872E-03 -2.2558E-04 2.2135E-04 -4.1954E-03 7.5806E-04 -2.7540E-03 -1.4399E-03 Elapsed estimation time in seconds: 63.04 Elapsed covariance time in seconds: 3.14 NOTES FOR PDX-POP USERS: Steps 14 & 15 can be accomplished from the PDx-Pop Menu Toolbar (Tools > MPI Register). The test run (Step 16) can be accomplished by selecting the "example1" project directory, selecting the foce_parallel.ctl, checking the "-parafile=" option box and choosing the "mpiwini.pnm" with the drop-down selector on the Model/Run tab. Click the "Run" button to initiate the test run. William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 [email protected]