Dear group,
I am working on a retrospectively collected dataset from hospital based
subjects. I have only one trough measured for each subject after IV infusion.
My understanding is that we need at least two samples in the same subject to
estimate BSV and ISV. We would like to develop a population PK model with the
data to explore the potential optimization of the therapy using the model
simulations. I appreciate if you can direct me to the proper references and
any ideas on modeling. Also, I appreciate your comments on the parametric vs
nonparametric approaches in such scenarios where one performs better than
other, if at all.
Ayyappa Chaturvedula, PhD
Visiting Assistant Research Professor,
College of Pharmacy and Health Sciences,
Mercer University,
3001 Mercer University Drive,
Atlanta, GA 30341
6785476168 (O)
Single Trough Levels
Dear group,
I also have an interest in this sampling and analytical scenario for a project
that I am starting and would appreciate any direction you can provide.
Thank-you very much.
Brian Decker MD, PharmD
Assistant Professor of Clinical Medicine
Indiana University School of Medicine
1001 West 10th St. OPW526
Indianapolis, IN 46202
Quoted reply history
________________________________
From: [email protected] [[email protected]] on behalf of
Ayyappa Chaturvedula [[email protected]]
Sent: Saturday, July 16, 2011 4:40 PM
To: [email protected]
Subject: [NMusers] Single Trough Levels
Dear group,
I am working on a retrospectively collected dataset from hospital based
subjects. I have only one trough measured for each subject after IV infusion.
My understanding is that we need at least two samples in the same subject to
estimate BSV and ISV. We would like to develop a population PK model with the
data to explore the potential optimization of the therapy using the model
simulations. I appreciate if you can direct me to the proper references and
any ideas on modeling. Also, I appreciate your comments on the parametric vs
nonparametric approaches in such scenarios where one performs better than
other, if at all.
Ayyappa Chaturvedula, PhD
Visiting Assistant Research Professor,
College of Pharmacy and Health Sciences,
Mercer University,
3001 Mercer University Drive,
Atlanta, GA 30341
6785476168 (O)