REML implementation in NONMEM

1 messages 1 people Latest: Nov 16, 2007

REML implementation in NONMEM

From: Jeroen Elassaiss-Schaap Date: November 16, 2007 technical
Dear all, In the Yano, Beal & Sheiner paper that appeared in JPKPD vol 28(4) 2001: pg 389-412, the use of restricted maximum likelihood (REML) is discussed. In that paper the reader is referred to an old nonmem repository for its (apparently nontrivial) implementation in NONMEM. That link unfortunately is not alive anymore. So my question is: Could someone please provide me with a REML implementation for NONMEM or the aforementioned material? Best regards, Jeroen J. Elassaiss-Schaap Scientist PK/PD Organon NV PO Box 20, 5340 BH Oss, Netherlands Phone: + 31 412 66 9320 Fax: + 31 412 66 2506 e-mail: [EMAIL PROTECTED] PS: pubmed link to Yano article is http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uid s=11677933&dopt=Citation This message, including the attachments, is confidential and may be privileged. If you are not an intended recipient, please notify the sender then delete and destroy the original message and all copies. You should not copy, forward and/or disclose this message, in whole or in part, without permission of the sender.