References on NONMEM application

3 messages 3 people Latest: May 21, 1999

References on NONMEM application

From: Daniel Yuan Date: May 19, 1999 technical
From: "Daniel Yuan" <dzyuan@hotmail.com> To: nmusers@c255.ucsf.edu Subject: References on NONMEM application Date: Wed, 19 May 1999 06:54:16 PDT Does anybody know of publications/references where NONMEM has been used to model drug PK in a peripheral compartment (e.g, synovial fluid) where there is the issue of relating plasma population PK to the peripheral compartment? Your help is much appreciated Zhi Yuan, PhD Div Clin Pharma Uniformed Services University Bethesda, MD 20814

Re: References on NONMEM application

From: Jogarao Gobburu Date: May 19, 1999 technical
Date: Wed, 19 May 1999 16:20:28 -0500 (EDT) From: Jogarao Gobburu 301-594-5661 FAX 301480-8329 <GOBBURUJ@cder.fda.gov> Subject: Re: References on NONMEM application Previously, NONMEM has been used to model plasma and CSF concentrations in "Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children. Br J Clin Pharmacol. 1998 Sep;46(3):237-43". This work was done by Anderson, Nick Holford and others. The authors have used a link compartment approach (with a partition coefficient) in relating the plasma and the csf compartments. With regards, Joga Joga Gobburu Pharmacometrics, CDER, FDA

Re: References on NONMEM application

From: Acpphos Date: May 21, 1999 technical
Date: Fri, 21 May 1999 13:01:35 +0200 From: "acpphos" <acpphos@wanadoo.fr> Subject: Re: References on NONMEM application Here's one : M.Tod,C.Pobel,V.Le Gros,K.Louchahi, P.Petitjean,N.Brion. A population pharmacokinetic study of alminoprofen penetration into synovial fluid. Biopharm.Drug Dispos., 1995, 16, 627-634. Christian Pobel C.POBEL SERVICE DE PHARMACIE CLINIQUE CENTRE HOSPITALIER BP326 17108 SAINTES CEDEX T 33 5 46 92 76 20 F 33 5 46 92 77 14 christian.pobel@wanadoo.fr