Re: References on NONMEM application
Date: Wed, 19 May 1999 16:20:28 -0500 (EDT)
From: Jogarao Gobburu 301-594-5661 FAX 301480-8329 <GOBBURUJ@cder.fda.gov>
Subject: Re: References on NONMEM application
Previously, NONMEM has been used to model plasma and CSF concentrations in "Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children. Br J Clin Pharmacol. 1998 Sep;46(3):237-43". This work was done by Anderson, Nick Holford and others. The authors have used a link compartment approach (with a partition coefficient) in relating the plasma and the csf compartments.
With regards,
Joga
Joga Gobburu
Pharmacometrics,
CDER, FDA