Preclinical and Translational PK & PKPD Scientist at AstraZeneca
We are now looking for a preclinical and translational PK & PKPD scientist to
AstraZeneca in Mölndal, Sweden. You will work as a consultant at Proffice Life
Science and you will be placed in the CVMD iMed DMPK department, within
Modelling and Simulation, AstraZeneca Mölndal. The assignment is for two years,
until 2016-06-01 with a start as soon as possible.
Description:
This temporary role as a translational PK & PKPD scientist will help provide
projects with understanding and integration of the correlation between in-vitro
and in-vivo ADME properties and the relationship between pharmacokinetics (PK)
/toxicokinetics (TK) and pharmacodynamic (PD) responses including biomarkers
for mechanism of action.
Major responsibilities:
· Define and deliver the preclinical, translational PKPD strategy for
efficacy and safety, in projects from Target Identification to Life Cycle
Management
· Design preclinical and forward/backward translational PKPD and TKPD
studies and report results and interpretations to project teams
· Deliver drug-drug interaction (DDI) predictions and risk assessments
to project teams
· Contribute to estimation of safety margins and make recommendations
and predictions on human efficacious dose and exposure
· Evaluate and interpret PKPD and TKPD data to prepare for internal
governance bodies
· Work collaboratively with other functions as needed to deliver the
above (e.g. bioscientists, translational scientists, safety scientists,
clinical pharmacology and pharmacometricians)
· Document the work according to AstraZeneca GLS standards
· Contribute proactively to a vibrant and innovative working
environment where improvements and new ideas are adopted and freely shared
Key Deliverables:
· Deliver the PK, DDI, PKPD and TKPD elements to project teams within
the agreed timelines and to the right quality
Qualification:
· PhD or equivalent level of experience in quantitative PK and PD
related modelling & simulation of biological systems, ideally in a
preclinical/translational setting
· Track record of defining quantitative modelling strategies across
several therapeutic modalities (e.g. small molecules, oligonucleotides,
proteins, antibodies)
· Track record of ability to meet timelines to pre-specified quality
and cost
· Specialist in modelling and simulation tools such as NONMEM,
WinNonlin/Phoenix, Matlab, SimCyp
· Understanding of integrative aspects of DMPK and pharmacology/safety
aspects of drug discovery and development
· Experience in pharmaceutical R&D
· Experience in operating cross-functionally
The successful candidate should have a strategic thinking and be a
communicative team player that likes to work within a group and collaborate
while meeting deadlines. As a person you should be organized, accurate and be
able to work independently. Also, the perfect candidate should have a passion
for customers as well as develop people and organisation. Personal qualities
will be important in the selection process. Please specify your knowledge for
this position and why you are the perfect candidate for this assignment.
Deadline for applications: 2014-06-09, selection is done continuously
For further information and application:
http://www.proffice.se/Jobb-karriar/Lediga-tjanster/Jobb/Senior-Scientist-in-PK--PKPD--200585018/?backUrl=1
Kind regards,
Rasmus Jansson Löfmark, PhD
Modelling and Simulation
Associate Principal Scientist, iMed DMPK CVMD
AstraZeneca R&D Mölndal, Sweden
Phone +46 31 776 1109
[email protected]<mailto:[email protected]>
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