Preclinical and Translational PK & PKPD Scientist at AstraZeneca

Preclinical and Translational PK & PKPD Scientist at AstraZeneca We are now looking for a preclinical and translational PK & PKPD scientist to AstraZeneca in Mölndal, Sweden. You will work as a consultant at Proffice Life Science and you will be placed in the CVMD iMed DMPK department, within Modelling and Simulation, AstraZeneca Mölndal. The assignment is for two years, until 2016-06-01 with a start as soon as possible. Description: This temporary role as a translational PK & PKPD scientist will help provide projects with understanding and integration of the correlation between in-vitro and in-vivo ADME properties and the relationship between pharmacokinetics (PK) /toxicokinetics (TK) and pharmacodynamic (PD) responses including biomarkers for mechanism of action. Major responsibilities: · Define and deliver the preclinical, translational PKPD strategy for efficacy and safety, in projects from Target Identification to Life Cycle Management · Design preclinical and forward/backward translational PKPD and TKPD studies and report results and interpretations to project teams · Deliver drug-drug interaction (DDI) predictions and risk assessments to project teams · Contribute to estimation of safety margins and make recommendations and predictions on human efficacious dose and exposure · Evaluate and interpret PKPD and TKPD data to prepare for internal governance bodies · Work collaboratively with other functions as needed to deliver the above (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacology and pharmacometricians) · Document the work according to AstraZeneca GLS standards · Contribute proactively to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared Key Deliverables: · Deliver the PK, DDI, PKPD and TKPD elements to project teams within the agreed timelines and to the right quality Qualification: · PhD or equivalent level of experience in quantitative PK and PD related modelling & simulation of biological systems, ideally in a preclinical/translational setting · Track record of defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, proteins, antibodies) · Track record of ability to meet timelines to pre-specified quality and cost · Specialist in modelling and simulation tools such as NONMEM, WinNonlin/Phoenix, Matlab, SimCyp · Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development · Experience in pharmaceutical R&D · Experience in operating cross-functionally The successful candidate should have a strategic thinking and be a communicative team player that likes to work within a group and collaborate while meeting deadlines. As a person you should be organized, accurate and be able to work independently. Also, the perfect candidate should have a passion for customers as well as develop people and organisation. Personal qualities will be important in the selection process. Please specify your knowledge for this position and why you are the perfect candidate for this assignment. Deadline for applications: 2014-06-09, selection is done continuously For further information and application: http://www.proffice.se/Jobb-karriar/Lediga-tjanster/Jobb/Senior-Scientist-in-PK--PKPD--200585018/?backUrl=1 Kind regards, Rasmus Jansson Löfmark, PhD Modelling and Simulation Associate Principal Scientist, iMed DMPK CVMD AstraZeneca R&D Mölndal, Sweden Phone +46 31 776 1109 [email protected]<mailto:[email protected]> -------------------------------------------------------------------------- Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.