US Postdoctoral Opportunity Pharmacology- pharmacokinetics (PBPK) modeling
Position Title: Pediatric physiologically based pharmacokinetics (PBPK)
modeling to guide clinical trial design
At AstraZeneca We are seeking talented scientists who are interested in
pursuing an academic-style Postdoc in a global pharmaceutical setting and
contributing to AstraZeneca's commitment to delivering innovative medicines.
This newly expanded internal pharmaceutical Postdoctoral research program spans
multiple therapeutic areas and a wide range of scientific disciplines.
Your comprehensive training program includes a focus on drug discovery and
development, as well as exposure to existing local and global Postdoctoral
Research communities within AstraZeneca. Postdoctoral scientists will have the
opportunity to conduct independent cutting-edge work in state-of-the-art
laboratories while teaming with other AstraZeneca scientists.
Each Postdoctoral scientist will also be able to collaborate with a leading
academic advisor who will provide further support and guidance. Additionally,
the Postdoc will be encouraged to attend and present at international
scientific conferences and publish high-profile papers.
Major responsibilities:
* Perform literature searches and evaluate available clinical pediatric reports
* Collection of both preclinical and clinical adult and pediatric data for
identified drugs
* Develop PBPK models and population allometric scaling models with the
collected data
* Develop an approach to compare pros and cons of both methodology and propose
good practice based on findings
* Validate proposed good practices with emerging data
* Develop skills in both clinical pharmacology and pharmacometrics and it's
impact in drug development process especially toward pediatric development
* Willing to develop and freely share new idea to improve or enhance current
process
* Actively engaged with all the AZ and academic supervisors
* Collaborate with other scientist within Astrazenca global while able to work
solitarily
* Publish scientific papers describing findings from the project and especially
any novel method/approaches
Key deliverables:
Delivery of modelling and data analysis methods for the collected data and
proposed good practice/recommendation
Candidate Knowledge, Skills and Experience
Minimum Requirements:
* A PhD in pharmacokinetics, drug metabolism, pharmacology, mathematics,
biomedical engineering or relevant discipline:
Preferred experience
* Pharmacokinetic modelling, physiologically based pharmacokinetic (PBPK)
modelling or systems biology modeling.
* Mathematical or statistical modelling with experience in modelling biological
data.
* Application of specialist in tools such as SIMCYP, Phoenix, WinNonlin,
Matlab, NONMEM, R,
* Understanding of DMPK and pharmacology/safety, drug delivery,
pharmacokinetic, pharmacodynamic and pediatric aspects of drug discovery and
development
Skills and Capabilities:
* Good team working and networking skills.
* Able to demonstrate the drive and energy to deliver projects.
* Demonstrate a high degree of personal credibility.
* Work collaboratively within a team and networking
* Ability to share knowledge and interpret findings
* Strong interpersonal, organizational and communication skills
* A strong scientific track record, as evidenced by published or accepted
papers in peer-reviewed journals, oral and/or poster presentations at
scientific meetings
* Strong commitment to science and ability to work well within a group
environment
* Good communication skill as the position will require working with colleague
in cross-geographic locations.
* Collaborative and interactive personality
Location: MA, Waltham
Please contact Amy Cheung ([email protected]) and Diansong Zhou
([email protected]) for more information.
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