Postdoctoral Opportunity Pharmacology- pharmacokinetics (PBPK) modeling at AstraZeneca

US Postdoctoral Opportunity Pharmacology- pharmacokinetics (PBPK) modeling Position Title: Pediatric physiologically based pharmacokinetics (PBPK) modeling to guide clinical trial design At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines. Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists. Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers. Major responsibilities: * Perform literature searches and evaluate available clinical pediatric reports * Collection of both preclinical and clinical adult and pediatric data for identified drugs * Develop PBPK models and population allometric scaling models with the collected data * Develop an approach to compare pros and cons of both methodology and propose good practice based on findings * Validate proposed good practices with emerging data * Develop skills in both clinical pharmacology and pharmacometrics and it's impact in drug development process especially toward pediatric development * Willing to develop and freely share new idea to improve or enhance current process * Actively engaged with all the AZ and academic supervisors * Collaborate with other scientist within Astrazenca global while able to work solitarily * Publish scientific papers describing findings from the project and especially any novel method/approaches Key deliverables: Delivery of modelling and data analysis methods for the collected data and proposed good practice/recommendation Candidate Knowledge, Skills and Experience Minimum Requirements: * A PhD in pharmacokinetics, drug metabolism, pharmacology, mathematics, biomedical engineering or relevant discipline: Preferred experience * Pharmacokinetic modelling, physiologically based pharmacokinetic (PBPK) modelling or systems biology modeling. * Mathematical or statistical modelling with experience in modelling biological data. * Application of specialist in tools such as SIMCYP, Phoenix, WinNonlin, Matlab, NONMEM, R, * Understanding of DMPK and pharmacology/safety, drug delivery, pharmacokinetic, pharmacodynamic and pediatric aspects of drug discovery and development Skills and Capabilities: * Good team working and networking skills. * Able to demonstrate the drive and energy to deliver projects. * Demonstrate a high degree of personal credibility. * Work collaboratively within a team and networking * Ability to share knowledge and interpret findings * Strong interpersonal, organizational and communication skills * A strong scientific track record, as evidenced by published or accepted papers in peer-reviewed journals, oral and/or poster presentations at scientific meetings * Strong commitment to science and ability to work well within a group environment * Good communication skill as the position will require working with colleague in cross-geographic locations. * Collaborative and interactive personality Location: MA, Waltham Please contact Amy Cheung ([email protected]) and Diansong Zhou ([email protected]) for more information. -------------------------------------------------------------------------- AstraZeneca UK Limited is a company incorporated in England and Wales with registered number: 03674842 and a registered office at 2 Kingdom Street, London, W2 6BD. 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