From: Sohn, Winnie <[email protected]>
Sent: Monday, May 14, 2018 8:41 PM
To: Nick Holford <[email protected]>
Subject: RE: Using Root-finding techniques to find Cmax/Tmax
Hi Nick,
I have tried to unsubscribe multiple times to NMusers. Can you please help?
Thanks,
Winnie
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Nick Holford
Sent: Monday, May 14, 2018 11:30 AM
To: Bauer, Robert <[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: [external] [NMusers] RE: Using Root-finding techniques to find
Cmax/Tmax
Bob,
Thanks for the zip file.
And for the motivation to explore intro7.pdf – always something interesting to
learn in the modelling world (unlike those stuck in the NCA doldrums).
Nick
From: Bauer, Robert <[email protected]<mailto:[email protected]>>
Sent: Monday, May 14, 2018 7:16 PM
To: Nick Holford <[email protected]<mailto:[email protected]>>;
[email protected]<mailto:[email protected]>
Subject: RE: Using Root-finding techniques to find Cmax/Tmax
Nick:
A cmax_root_finder.zip file is now supplied.
nonmem_reserved_general is not intended to be humanly read, but used in the
control stream for easy access of reserved variables. A copy is also in
..\util of your NONMEM installation. Use of it is described in
..\guides\intro7.pdf
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
www.iconplc.com_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=59XSQi0f1WJqQwbCSm4TIyGoFCN5a2fZp6h-rPTTEIo&e=">https://urldefense.proofpoint.com/v2/url?u=http-3A__www.iconplc.com_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=59XSQi0f1WJqQwbCSm4TIyGoFCN5a2fZp6h-rPTTEIo&e=
Quoted reply history
From: Nick Holford [mailto:[email protected]]
Sent: Monday, May 14, 2018 9:54 AM
To: Bauer, Robert; [email protected]<mailto:[email protected]>
Subject: RE: Using Root-finding techniques to find Cmax/Tmax
Hi Bob,
Thanks for preparing the examples. I found the “nonmem reserved general” file
something of a challenge – I could barely understand a line of it.
Any chance you could zip up all the files into one archive file? I find myself
faced with downloading a couple of pages of files one file at a time.
Best wishes,
Nick
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72
email: [email protected]<mailto:[email protected]>
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Read the question, answer the question, attempt all questions
From: [email protected]<mailto:[email protected]>
<[email protected]<mailto:[email protected]>> On Behalf
Of Bauer, Robert
Sent: Monday, May 14, 2018 5:55 PM
To: [email protected]<mailto:[email protected]>
Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax
Dear nmusers:
Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the
proper way of obtaining tmax and cmax with ODE solvers, I have been motivated
to provide some examples utilizing root-finding techniques available in ADVAN14
(CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view
the accompanying example files, located in
https://urldefense.proofpoint.com/v2/url?u=https-3A__nonmem.iconplc.com_nonmem_cmax-5Froot-5Ffinder&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=j8gIhRuX6BEDI20rEvlAkqTz4VdJca56C0s5cTyNCYY&e=
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
www.iconplc.com_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=59XSQi0f1WJqQwbCSm4TIyGoFCN5a2fZp6h-rPTTEIo&e=">https://urldefense.proofpoint.com/v2/url?u=http-3A__www.iconplc.com_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=59XSQi0f1WJqQwbCSm4TIyGoFCN5a2fZp6h-rPTTEIo&e=