Job Title: Preclinical Pharmacokinetics Scientist/Sr Scientist
Req Number: zymo-00000574
Department: 442 - Pre-Clinical Development
Hiring Manager: Kelly Byrnes-Blake
Recruiter: Sandi Jones <[EMAIL PROTECTED]>
ZymoGenetics is hiring a scientist to provide pharmacokinetic expertise
and leadership for novel protein research candidates and development
programs.
Specific Responsibilities:
* Provide expertise and consultation in the area of pharmacokinetics for
large biologically-based molecules.
* Design, analyze, interpret, report, and present pharmacokinetic data
from preclinical and clinical studies, in accord with applicable
regulatory guidelines.
* Actively participate in the planning, implementing and monitoring of
both internal and contracted pharmacokinetic studies.
* Contribute to generating and reviewing documents such as
investigator's brochures, INDs, and BLAs.
* Provide scientific expertise and leadership on issues regarding
pharmacokinetics and dose/regimen selection for preclinical
pharmacology, toxicology and first-in-human studies.
* Identify and investigate the relationship between pharmacokinetics and
efficacy/safety biomarkers in preclinical studies, and advise on their
relevance to the clinic.
* Manage multiple projects across a broad pipeline of drug candidates.
* Effectively work with multidisciplinary teams (toxicology,
pharmacology, regulatory affairs, clinical development, research, CMC
and others) and represent the preclinical department effectively on
project teams.
* Provide complex communications under tight timelines. Communicate
relevant facts to management and project teams clearly and concisely.
Serve as a facilitator to ensure that appropriate individuals are
involved in key decision-making and interpretive efforts.
* Prepare scientific publications and presentations for internal and
external venues.
* Ph.D. in pharmacokinetics, pharmacology, biopharmaceutics, or related
field
* At least 3 years relevant pharmaceutical industry experience
* Proficient in using WinNonlin, NONMEM, Adapt II, Madonna, MATLAB, or
other relevant pharmacokinetic software for pharmacokinetic analysis and
modeling
* Ability to work collaboratively in a team environment
* Demonstrated written, oral, and interpersonal communication skills
through publications, meeting abstracts and/or presentations, and
regulatory filings
* Experience in the pharmacokinetic evaluation of antibodies and other
protein therapeutics is a plus
* Experience with the population approach, complex PK/PD modeling, PBPK
approaches and simulation is a plus
* Experience in animal handling and dosing is a plus
To Apply:
Located in the historic City Light building on Seattle's Lake Union,
ZymoGenetics offers competitive employment packages that include
employer sponsored healthcare, paid time off for sick and vacation, 12
paid holidays, matching 401K program, stock options and tuition
reimbursement to name only a few of our terrific benefits.
For confidential consideration, visit the career page of our website to
apply online at: www.zymogenetics.com or email: [EMAIL PROTECTED]
Please reference the Source Code ZYMO-0574 in the subject line. If
including a cover letter, please place/paste before the resume. Or mail:
ZymoGenetics, Inc., Unit 247, Source Code ZYMO-0574, P. O. Box 3175,
Burlington, MA 01803. We are an equal opportunity employer and encourage
applications from women and minorities.
----
Mike Dodds, PhD
PK/PD, Pre-clinical Development
ZymoGenetics, Inc.
1201 Eastlake Avenue
Seattle, WA, 98102, USA
Tel: 206-442-6737
Email: [EMAIL PROTECTED]
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