PK/PD Job Available, Pacific Northwest Biotech

Job Title: Preclinical Pharmacokinetics Scientist/Sr Scientist Req Number: zymo-00000574 Department: 442 - Pre-Clinical Development Hiring Manager: Kelly Byrnes-Blake Recruiter: Sandi Jones <[EMAIL PROTECTED]> ZymoGenetics is hiring a scientist to provide pharmacokinetic expertise and leadership for novel protein research candidates and development programs. Specific Responsibilities: * Provide expertise and consultation in the area of pharmacokinetics for large biologically-based molecules. * Design, analyze, interpret, report, and present pharmacokinetic data from preclinical and clinical studies, in accord with applicable regulatory guidelines. * Actively participate in the planning, implementing and monitoring of both internal and contracted pharmacokinetic studies. * Contribute to generating and reviewing documents such as investigator's brochures, INDs, and BLAs. * Provide scientific expertise and leadership on issues regarding pharmacokinetics and dose/regimen selection for preclinical pharmacology, toxicology and first-in-human studies. * Identify and investigate the relationship between pharmacokinetics and efficacy/safety biomarkers in preclinical studies, and advise on their relevance to the clinic. * Manage multiple projects across a broad pipeline of drug candidates. * Effectively work with multidisciplinary teams (toxicology, pharmacology, regulatory affairs, clinical development, research, CMC and others) and represent the preclinical department effectively on project teams. * Provide complex communications under tight timelines. Communicate relevant facts to management and project teams clearly and concisely. Serve as a facilitator to ensure that appropriate individuals are involved in key decision-making and interpretive efforts. * Prepare scientific publications and presentations for internal and external venues. * Ph.D. in pharmacokinetics, pharmacology, biopharmaceutics, or related field * At least 3 years relevant pharmaceutical industry experience * Proficient in using WinNonlin, NONMEM, Adapt II, Madonna, MATLAB, or other relevant pharmacokinetic software for pharmacokinetic analysis and modeling * Ability to work collaboratively in a team environment * Demonstrated written, oral, and interpersonal communication skills through publications, meeting abstracts and/or presentations, and regulatory filings * Experience in the pharmacokinetic evaluation of antibodies and other protein therapeutics is a plus * Experience with the population approach, complex PK/PD modeling, PBPK approaches and simulation is a plus * Experience in animal handling and dosing is a plus To Apply: Located in the historic City Light building on Seattle's Lake Union, ZymoGenetics offers competitive employment packages that include employer sponsored healthcare, paid time off for sick and vacation, 12 paid holidays, matching 401K program, stock options and tuition reimbursement to name only a few of our terrific benefits. For confidential consideration, visit the career page of our website to apply online at: www.zymogenetics.com or email: [EMAIL PROTECTED] Please reference the Source Code ZYMO-0574 in the subject line. If including a cover letter, please place/paste before the resume. Or mail: ZymoGenetics, Inc., Unit 247, Source Code ZYMO-0574, P. O. Box 3175, Burlington, MA 01803. We are an equal opportunity employer and encourage applications from women and minorities. ---- Mike Dodds, PhD PK/PD, Pre-clinical Development ZymoGenetics, Inc. 1201 Eastlake Avenue Seattle, WA, 98102, USA Tel: 206-442-6737 Email: [EMAIL PROTECTED] CONFIDENTIALITY NOTICE: The information contained in this email is intended for the named recipient(s) only. It may contain privileged and confidential information. Any review, retransmission, dissemination or other use of, or taking of any action in reliance upon, this information by persons or entities other than the intended recipient(s) is prohibited. If you are not the addressee or the person responsible for delivering this to the addressee, or have received this e-mail in error, please notify us immediately by returning the original message to the sender by e-mail and deleting the material from any computer.