We have two workshops before PAGE that you may find interesting, they can
easily be found here at our training site
https://www.certarauniversity.com/store?utf8=%E2%9C%93&ss=1&ct=102967&commit=Filter
Workshop: An Introduction to CAR-T Population Kinetic
https://www.certarauniversity.com/store/3090941-workshop-an-introduction-to-car-t-population-kinetic-analysis
27th June 2023 8 AM-12
Facilitators: Mirjam Trame and Stephen Duffull
This hands-on workshop will provide an introduction to CAR-T population kinetic
analysis and CAR-T concepts including:
* therapeutic utility and challenges in drug development of CAR-T
initiatives
* the basis for understanding the cellular kinetics of CAR-T cells
* models that have been used to describe the kinetics of CAR-T cells and
typical inferences
* CAR-T cell kinetic modelling
The workshop consists of lectures and interactive hands-on sessions using
NONMEM and R. During the hands-on session participants will have the
opportunity to explore CAR-T cell data and key features of cellular kinetics as
well as fit base models to cellular kinetic data in order to understand the
nuances of CAR-T cell kinetic modeling for autologous and allogenic CAR-T cell
therapies.
It is expected that participants will bring their own devices and have access
to and familiarity with NONMEM and R.
Tutorial: Effective Visualizations for Pharmacometric Models
https://www.certarauniversity.com/store/3082574-tutorial-effective-visualizations-for-pharmacometric-models-vachette
27th June 2023 1:00 PM 5:00 PM
Visualization of pharmacometrics models and data is often central to
effectively informing drug discovery and development decisions. A previously
published method (V2ACHERa) yielded an intuitive, clear visual overlay of data
for certain GNLS, GLM, and NLME models, allowing an integrated display (in a
single plot) of model predictions and data from different groups (i.e. across
covariate-value-defined subgroups).
This four-hour, hands-on tutorial will teach you how to use VACHETTEb, an
improved and automated method enabling improved visualizations for PMX models
with covariates, improving assessment and communication of model fit for both
modelers and non-modelers. VACHETTE can also be applied to overlay data and
models or for visual predictive checks (VPC), often yielding improved
interpretability compared to traditional trellis plots, VPC, or pcVPC.
The workshop will include lectures and hands-on exercises. Participants can
also bring their own examples. The VACHETTE tutorial will use an open-source R
package developed by Certara that will be freely available shortly.
And you can access a special bundle pricing CAR-T workshop + VACHETTE
visualization tutorial
https://www.certarauniversity.com/store/4174-page-2023-car-t-workshop-vachette-visualization-tutorial-bundle?is_bundle=1
Simon DAVIS,
Senior Support Scientist, Certara.
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