From: rcalvo@lg.ehu.es
Subject: [NMusers] Oral partitioned dose
Date: 8/25/2003 12:30 AM
Dear Members:
I am using NONMEM to perform population modeling in a preclinical study.
Can anybody tell me how i can specify in NONMEM data file (in dose column)
that a dose is partitioned into two compartments.
After p.o. drug administration, part of the dose gets solved (CMT 1) and
the rest precipitates (CMT 2).
Thanks in advance for your coperation
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Rosario Calvo Duo, PhD
Department of Pharmacology
Faculty of Medicine
University of the Basque
Leioa, Vizcaya 48940
Spain
tel: +34 946012761 UTC+1hour
fax: +34 944800128
http://www.ehu.es
Oral partitioned dose
From: PASCAL.GIRARD@adm.univ-lyon1.fr
Subject: RE : [NMusers] Oral partitioned dose
Date: 8/25/2003 7:40 AM
Dear Charo,
In addition to the AMT column, you will need a CMT one specifying the
compartment number, according to the ADVAN you chose, where the dose has
to be put. You may also want to use a RATE column specifying whether the
dose is a bolus or an infusion, if your model includes zero order absorption
for one of the compartment. Look at help files for all this. Finally you
probably will have also to use Fx the bioavailability parameter in $PK
where x is the compartment number of your dose. In your example
F1, where 0 < F1 < 1, will be the proportion of dose getting solved
and F2 = 1-F1 the proportion of dose getting precipitated.
Best,
Dr Pascal Girard
Lab de Bactriologie
Fac Mdecine Lyon-Sud
BP12
69921 OULLINS Cedex
France
Tel 33 4 78 86 31 53
Fax 33 4 78 86 31 49
e-mail : Pascal.Girard@adm.univ-lyon1.fr
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