Optimal sampling points

5 messages 4 people Latest: Feb 15, 2000

Optimal sampling points

From: Huitema Alwin Date: February 08, 2000 technical
Date: Tue, 08 Feb 2000 08:58:00 +0100 From: Huitema Alwin <APAHU@slz.nl> Subject: Optimal sampling points We have the following problem. We want to estimate individual PK parameters using a Bayesian approach with sparse individual data based on a prior population PK analysis. We have selected optimal sampling times using the D-optimality criterion as incorporated in ADAPT II using the typical values calculated from the population PK analysis. This criterion is, however, not optimal since it is designed when data are analyzed without reference to a prior distribution. Does anyone know how to select optimal sampling points for a Bayesian estimation procedure and how this is practically performed? Alwin Huitema

Optimal sampling points

From: Lewis B. Sheiner Date: February 08, 2000 technical
Date: Tue, 08 Feb 2000 08:21:27 -0800 From: LSheiner <lewis@c255.ucsf.edu> Subject: Optimal sampling points You might try loking at the work of Mentre & coworkers, J Pharmacokin Biopharmaceut 23: 101, 1995; Stat in Med 13: 185, 1994. LBS. -- _/ _/ _/_/ _/_/_/ _/_/_/ Lewis B Sheiner, MD (lewis@c255.ucsf.edu) _/ _/ _/ _/_ _/_/ Professor: Lab. Med., Bioph. Sci., Med. _/ _/ _/ _/ _/ Box 0626, UCSF, SF, CA, 94143-0626 _/_/ _/_/ _/_/_/ _/ 415-476-1965 (v), 415-476-2796 (fax) Date: Wed, 09 Feb 2000 21:48:54 -0500

Re: Optimal sampling points

From: Bill Gillespie Date: February 10, 2000 technical
From: Bill Gillespie <bgillespie@pharsight.com> Subject: Re: Optimal sampling points There is a body of literature on Bayesian optimal design and optimal sampling times would be a special case. Some recent work is described in: P Müller. Simulation based optimal design. in JM Bernardo, JO Berger, AP Dawid, AFM Smith (eds.). Bayesian Statistics 6. Oxford Univ. Press (1998). GL Rosner. Simulation-based methods of determining optimal sampling times. Presented at BMSR Modeling Workshop 1999. Both authors are located at Duke ( http://www.stat.duke.edu/ ). Bill Gillespie Huitema Alwin wrote:

Optimal sampling times

From: Huitema Alwin Date: February 15, 2000 technical
Date: Tue, 15 Feb 2000 12:46:13 +0100 From: Huitema Alwin <APAHU@slz.nl> Subject: Optimal sampling times We have recently asked for methods for obtaining optimal sampling times for Bayesian estimation with knowledge of the prior distribution. We are aware of literature on this issue (e.g. Mentre in JPB), but we do not have any experience in applying these techniques. Is there any readily available software package in which these calculations are incorporated? Alwin Huitema

RE: Optimal sampling times

From: Geoffrey J Yuen Date: February 15, 2000 technical
From: "Yuen, Geoffrey J" <gjy25826@glaxowellcome.com> Subject: RE: Optimal sampling times Date: Tue, 15 Feb 2000 10:04:57 -0500 The previous e-mails had listed a website at Duke University that details some of the software available (it's called BUGS). Geoffrey Yuen, Pharm.D. Clinical Pharmacokineticist Glaxo-Wellcome 5 Moore Drive RTP, NC 27709 phone 919 483 5676 email gjy25826@glaxowellcome.com