Optimal sampling points

From: Huitema Alwin Date: February 08, 2000 technical Source: cognigencorp.com
Date: Tue, 08 Feb 2000 08:58:00 +0100 From: Huitema Alwin <APAHU@slz.nl> Subject: Optimal sampling points We have the following problem. We want to estimate individual PK parameters using a Bayesian approach with sparse individual data based on a prior population PK analysis. We have selected optimal sampling times using the D-optimality criterion as incorporated in ADAPT II using the typical values calculated from the population PK analysis. This criterion is, however, not optimal since it is designed when data are analyzed without reference to a prior distribution. Does anyone know how to select optimal sampling points for a Bayesian estimation procedure and how this is practically performed? Alwin Huitema

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Feb 08, 2000 Huitema Alwin Optimal sampling points
Feb 08, 2000 Lewis B. Sheiner Optimal sampling points
Feb 10, 2000 Bill Gillespie Re: Optimal sampling points
Feb 15, 2000 Huitema Alwin Optimal sampling times
Feb 15, 2000 Geoffrey J Yuen RE: Optimal sampling times
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