GlaxoSmithKline R&D (GSK) is committed to model-based approaches to enhance the
quality and efficiency of drug development. We have an exciting opportunity
within our Clinical Pharmacology Modeling and Simulation Department (Oncology)
either in North Carolina (Research Triangle Park) or Pennsylvania (Upper
Merion). We are looking for a motivated individual with an established track
record in effectively applying clinical pharmacology principles and
pharmacometric methodologies in order to aid rational and informed decision
making in drug development.
The role requires doctorate level training (Ph.D., Pharm.D., or M.D.) and at
least 2 years of pharmaceutical industry experience. Experience in oncology is
preferred. Understanding of pharmacokinetic (PK) and pharmacodynamic (PD)
principles, have extensive experience in population PK/PD modeling and
simulation using NONMEM, S-PLUS, and/or other relevant tools, have worked with
WinNonlin and other commonly used PK and PK/PD software. Experience in
planning, designing, interpreting and reporting of clinical PK and PK/PD
studies, creating clinical pharmacology development plans, and writing the
relevant components of regulatory documents is essential
You will be responsible for influencing the strategy and contents of clinical
development plans and for the design, analysis and interpretation of PK and
PKPD data from clinical studies. Mathematical and statistical modeling and
simulation will be your primary tools to timely design, analyze and interpret
clinical trials. You will have the opportunity to explore, learn and utilize
state-of-the-art methodologies to help shape our question-based product
development plans and aid in dose selection. You will be working across the GSK
drug discovery pipeline from pre-candidate selection through post-licensing
within therapeutically-aligned groups.
An analytical and inquisitive mind for problem solving and strong written and
oral communication skills are essential. Ability to work well and form
effective relationships with interdisciplinary teams are necessary for
collaborative work in our matrix environment. Ability to effectively represent
Clinical Pharmacology Modeling and Simulation on internal teams and to external
groups. Ability to work independently and prioritize assignments with minimal
supervision
Interested individuals are encouraged to apply on line at GSK.com or contact
Dr. Daniele Ouellet
([email protected]<mailto:[email protected]>) for details about
the position.