Opportunity at GlaxoSmithKline

GlaxoSmithKline R&D (GSK) is committed to model-based approaches to enhance the quality and efficiency of drug development. We have an exciting opportunity within our Clinical Pharmacology Modeling and Simulation Department (Oncology) either in North Carolina (Research Triangle Park) or Pennsylvania (Upper Merion). We are looking for a motivated individual with an established track record in effectively applying clinical pharmacology principles and pharmacometric methodologies in order to aid rational and informed decision making in drug development. The role requires doctorate level training (Ph.D., Pharm.D., or M.D.) and at least 2 years of pharmaceutical industry experience. Experience in oncology is preferred. Understanding of pharmacokinetic (PK) and pharmacodynamic (PD) principles, have extensive experience in population PK/PD modeling and simulation using NONMEM, S-PLUS, and/or other relevant tools, have worked with WinNonlin and other commonly used PK and PK/PD software. Experience in planning, designing, interpreting and reporting of clinical PK and PK/PD studies, creating clinical pharmacology development plans, and writing the relevant components of regulatory documents is essential You will be responsible for influencing the strategy and contents of clinical development plans and for the design, analysis and interpretation of PK and PKPD data from clinical studies. Mathematical and statistical modeling and simulation will be your primary tools to timely design, analyze and interpret clinical trials. You will have the opportunity to explore, learn and utilize state-of-the-art methodologies to help shape our question-based product development plans and aid in dose selection. You will be working across the GSK drug discovery pipeline from pre-candidate selection through post-licensing within therapeutically-aligned groups. An analytical and inquisitive mind for problem solving and strong written and oral communication skills are essential. Ability to work well and form effective relationships with interdisciplinary teams are necessary for collaborative work in our matrix environment. Ability to effectively represent Clinical Pharmacology Modeling and Simulation on internal teams and to external groups. Ability to work independently and prioritize assignments with minimal supervision Interested individuals are encouraged to apply on line at GSK.com or contact Dr. Daniele Ouellet ([email protected]<mailto:[email protected]>) for details about the position.