Dear all
What are the major similarities and dissimilarities between NONMEM and
WinNonlin in modeling sparse dataset.
Bernard
NONMEM vs WinNonlin
Dear Bernard
NONMEM is command line software for mixed effects modelling, and is commonly
used for multiple subject compartmental modelling. There are eight different
minimization algorithms that you can use, individually or together. You can
usually iterate through model versions, changing initial conditions, boundary
conditions, error structure, etc. to achieve convergence. With this tool you
should be able to estimate some population parameters where sparse data is
available for multiple subjects. Some people prefer to use NONMEM in
conjunction with a third party graphical tool, such as Navigator, that includes
a menu system, visualization utilities and audit tools.
Pheonix WinNonlin is best known for its non-compartmental modelling, but also
allows single subject compartmental PKPD modelling. For sparse data it is
possible that even the simplest models will not converge. Also note that you
are calculating individual rather than population parameters. Pheonix NLME has
more similar functionality to NONMEM. The Pheonix products are built around a
graphical interface. You may also be interested in looking at Monolix, which is
another mixed effects modelling application.
Best wishes
Chris
Chris Campbell
Tel. +44 (0) 1249 705 450 | Mobile. +44 (0) 7929 628 349
[email protected] | http://www.mango-solutions.com
Mango Solutions, 2 Methuen Park, Chippenham, Wiltshire, SN14 OGB UK
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Bernard Ngara
Sent: 12 April 2013 15:49
To: nmusers
Subject: [NMusers] NONMEM vs WinNonlin
Dear all
What are the major similarities and dissimilarities between NONMEM and
WinNonlin in modeling sparse dataset.
Bernard
--
LEGAL NOTICE
This message is intended for the use of the named recipient(s) only and may
contain
confidential and / or privileged information. If you are not the intended
recipient, please
contact the sender and delete this message. Any unauthorised use of the
information
contained in this message is prohibited.
Mango Business Solutions Limited is registered in England under No. 4560258
with its
registered office at Suite 3, Middlesex House, Rutherford Close, Stevenage,
Herts, SG1 2EF,
UK.
PLEASE CONSIDER THE ENVIRONMENT BEFORE PRINTING THIS EMAIL
Bernard, I feel I should add to Chris's comments that with the release of the
Phoenix platform, not only did we vastly update and improve the general
WinNonlin environment and provide via the Connect license options to visually
link and manage NONMEM, R, PsN, Xpose etc. in a refreshable and "template-able"
workflow.
We also implemented NLME in the Phoenix model engine, which gives you a very
convenient GUI to access a range of algorithms, FOCE-ELS, FOCE-LB, Laplacian,
IT2S-EM, and QRPEM, as well as set up various Scenarios to assess covariates
etc.; if you will be at PAGE please consider attending one of our workshops
Categorical responses with Phoenix NLME 10-11 June, before PAGE, Glasgow, UK
Or the free Connect Workshop session on Tuesday afternoon 11 June; register
through the links here if you're interested;
http://www.pharsight.com/training/training_upcoming.php
Best regards,
Simon.
___________________________________
[email protected]
Senior Scientific Consultant, Pharsight- A CertaraT Company
March 2012 Phoenix 6.3, including the new QRPEM algorithm for NLME released.
January 2013 Reporter object for Phoenix 6.3.1 Connect released.
Get tips and discuss Pharsight products with other users;
www.pharsight.com/extranet
___________________________________
http://www.pharsight.com/training/training_upcoming.php
Introduction to Phoenix WinNonlin 25-27 June London, UK
Intermediate PK/PD Modelling with Phoenix WinNonlin 25-28 Jun, Amsterdam, NL.
Population Modeling Methodology using Phoenix NLME 24-26 September ,
Copenhagen, Denmark
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Chris Campbell
Sent: Wednesday, April 17, 2013 10:04 AM
To: Bernard Ngara
Cc: nmusers
Subject: RE: [NMusers] NONMEM vs WinNonlin
Dear Bernard
NONMEM is command line software for mixed effects modelling, and is commonly
used for multiple subject compartmental modelling. There are eight different
minimization algorithms that you can use, individually or together. You can
usually iterate through model versions, changing initial conditions, boundary
conditions, error structure, etc. to achieve convergence. With this tool you
should be able to estimate some population parameters where sparse data is
available for multiple subjects. Some people prefer to use NONMEM in
conjunction with a third party graphical tool, such as Navigator, that includes
a menu system, visualization utilities and audit tools.
Pheonix WinNonlin is best known for its non-compartmental modelling, but also
allows single subject compartmental PKPD modelling. For sparse data it is
possible that even the simplest models will not converge. Also note that you
are calculating individual rather than population parameters. Pheonix NLME has
more similar functionality to NONMEM. The Pheonix products are built around a
graphical interface. You may also be interested in looking at Monolix, which is
another mixed effects modelling application.
Best wishes
Chris
Chris Campbell
Tel. +44 (0) 1249 705 450 | Mobile. +44 (0) 7929 628 349
[email protected] | http://www.mango-solutions.com Mango Solutions,
2 Methuen Park, Chippenham, Wiltshire, SN14 OGB UK
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Bernard Ngara
Sent: 12 April 2013 15:49
To: nmusers
Subject: [NMusers] NONMEM vs WinNonlin
Dear all
What are the major similarities and dissimilarities between NONMEM and
WinNonlin in modeling sparse dataset.
Bernard
--
LEGAL NOTICE
This message is intended for the use of the named recipient(s) only and may
contain confidential and / or privileged information. If you are not the
intended recipient, please contact the sender and delete this message. Any
unauthorised use of the information contained in this message is prohibited.
Mango Business Solutions Limited is registered in England under No. 4560258
with its registered office at Suite 3, Middlesex House, Rutherford Close,
Stevenage, Herts, SG1 2EF, UK.
PLEASE CONSIDER THE ENVIRONMENT BEFORE PRINTING THIS EMAIL
Simon, Chris
I also wish to understand if the Phoenix platform depends on the type
of data(eg sparse/rich; single timepoint data). I understand that it
is something that can be done in Nonmem. Thank you.
Bernard
Quoted reply history
On 5/1/13, Simon Davis <[email protected]> wrote:
> Bernard, I feel I should add to Chris's comments that with the release of
> the Phoenix platform, not only did we vastly update and improve the general
> WinNonlin environment and provide via the Connect license options to
> visually link and manage NONMEM, R, PsN, Xpose etc. in a refreshable and
> "template-able" workflow.
>
> We also implemented NLME in the Phoenix model engine, which gives you a
> very convenient GUI to access a range of algorithms, FOCE-ELS, FOCE-LB,
> Laplacian, IT2S-EM, and QRPEM, as well as set up various Scenarios to assess
> covariates etc.; if you will be at PAGE please consider attending one of our
> workshops
>
> Categorical responses with Phoenix NLME 10-11 June, before PAGE, Glasgow,
> UK
>
> Or the free Connect Workshop session on Tuesday afternoon 11 June;
> register through the links here if you're interested;
> http://www.pharsight.com/training/training_upcoming.php
>
> Best regards,
> Simon.
>
> ___________________________________
> [email protected]
> Senior Scientific Consultant, Pharsight- A CertaraT Company
>
> March 2012 Phoenix 6.3, including the new QRPEM algorithm for NLME
> released.
> January 2013 Reporter object for Phoenix 6.3.1 Connect released.
> Get tips and discuss Pharsight products with other users;
> www.pharsight.com/extranet
> ___________________________________
> http://www.pharsight.com/training/training_upcoming.php
> Introduction to Phoenix WinNonlin 25-27 June London, UK
> Intermediate PK/PD Modelling with Phoenix WinNonlin 25-28 Jun, Amsterdam,
> NL.
> Population Modeling Methodology using Phoenix NLME 24-26 September ,
> Copenhagen, Denmark
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Chris Campbell
> Sent: Wednesday, April 17, 2013 10:04 AM
> To: Bernard Ngara
> Cc: nmusers
> Subject: RE: [NMusers] NONMEM vs WinNonlin
>
> Dear Bernard
>
> NONMEM is command line software for mixed effects modelling, and is commonly
> used for multiple subject compartmental modelling. There are eight different
> minimization algorithms that you can use, individually or together. You can
> usually iterate through model versions, changing initial conditions,
> boundary conditions, error structure, etc. to achieve convergence. With this
> tool you should be able to estimate some population parameters where sparse
> data is available for multiple subjects. Some people prefer to use NONMEM in
> conjunction with a third party graphical tool, such as Navigator, that
> includes a menu system, visualization utilities and audit tools.
>
> Pheonix WinNonlin is best known for its non-compartmental modelling, but
> also allows single subject compartmental PKPD modelling. For sparse data it
> is possible that even the simplest models will not converge. Also note that
> you are calculating individual rather than population parameters. Pheonix
> NLME has more similar functionality to NONMEM. The Pheonix products are
> built around a graphical interface. You may also be interested in looking at
> Monolix, which is another mixed effects modelling application.
>
> Best wishes
>
> Chris
>
>
> Chris Campbell
>
> Tel. +44 (0) 1249 705 450 | Mobile. +44 (0) 7929 628 349
> [email protected] | http://www.mango-solutions.com Mango
> Solutions, 2 Methuen Park, Chippenham, Wiltshire, SN14 OGB UK
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Bernard Ngara
> Sent: 12 April 2013 15:49
> To: nmusers
> Subject: [NMusers] NONMEM vs WinNonlin
>
> Dear all
>
> What are the major similarities and dissimilarities between NONMEM and
> WinNonlin in modeling sparse dataset.
>
> Bernard
>
> --
>
> LEGAL NOTICE
>
> This message is intended for the use of the named recipient(s) only and may
> contain confidential and / or privileged information. If you are not the
> intended recipient, please contact the sender and delete this message. Any
> unauthorised use of the information contained in this message is
> prohibited.
>
> Mango Business Solutions Limited is registered in England under No. 4560258
> with its registered office at Suite 3, Middlesex House, Rutherford Close,
> Stevenage, Herts, SG1 2EF, UK.
>
> PLEASE CONSIDER THE ENVIRONMENT BEFORE PRINTING THIS EMAIL
>
>
>