Re: NONMEM vs WinNonlin
Simon, Chris
I also wish to understand if the Phoenix platform depends on the type
of data(eg sparse/rich; single timepoint data). I understand that it
is something that can be done in Nonmem. Thank you.
Bernard
Quoted reply history
On 5/1/13, Simon Davis <[email protected]> wrote:
> Bernard, I feel I should add to Chris's comments that with the release of
> the Phoenix platform, not only did we vastly update and improve the general
> WinNonlin environment and provide via the Connect license options to
> visually link and manage NONMEM, R, PsN, Xpose etc. in a refreshable and
> "template-able" workflow.
>
> We also implemented NLME in the Phoenix model engine, which gives you a
> very convenient GUI to access a range of algorithms, FOCE-ELS, FOCE-LB,
> Laplacian, IT2S-EM, and QRPEM, as well as set up various Scenarios to assess
> covariates etc.; if you will be at PAGE please consider attending one of our
> workshops
>
> Categorical responses with Phoenix NLME 10-11 June, before PAGE, Glasgow,
> UK
>
> Or the free Connect Workshop session on Tuesday afternoon 11 June;
> register through the links here if you're interested;
> http://www.pharsight.com/training/training_upcoming.php
>
> Best regards,
> Simon.
>
> ___________________________________
> [email protected]
> Senior Scientific Consultant, Pharsight- A CertaraT Company
>
> March 2012 Phoenix 6.3, including the new QRPEM algorithm for NLME
> released.
> January 2013 Reporter object for Phoenix 6.3.1 Connect released.
> Get tips and discuss Pharsight products with other users;
> www.pharsight.com/extranet
> ___________________________________
> http://www.pharsight.com/training/training_upcoming.php
> Introduction to Phoenix WinNonlin 25-27 June London, UK
> Intermediate PK/PD Modelling with Phoenix WinNonlin 25-28 Jun, Amsterdam,
> NL.
> Population Modeling Methodology using Phoenix NLME 24-26 September ,
> Copenhagen, Denmark
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Chris Campbell
> Sent: Wednesday, April 17, 2013 10:04 AM
> To: Bernard Ngara
> Cc: nmusers
> Subject: RE: [NMusers] NONMEM vs WinNonlin
>
> Dear Bernard
>
> NONMEM is command line software for mixed effects modelling, and is commonly
> used for multiple subject compartmental modelling. There are eight different
> minimization algorithms that you can use, individually or together. You can
> usually iterate through model versions, changing initial conditions,
> boundary conditions, error structure, etc. to achieve convergence. With this
> tool you should be able to estimate some population parameters where sparse
> data is available for multiple subjects. Some people prefer to use NONMEM in
> conjunction with a third party graphical tool, such as Navigator, that
> includes a menu system, visualization utilities and audit tools.
>
> Pheonix WinNonlin is best known for its non-compartmental modelling, but
> also allows single subject compartmental PKPD modelling. For sparse data it
> is possible that even the simplest models will not converge. Also note that
> you are calculating individual rather than population parameters. Pheonix
> NLME has more similar functionality to NONMEM. The Pheonix products are
> built around a graphical interface. You may also be interested in looking at
> Monolix, which is another mixed effects modelling application.
>
> Best wishes
>
> Chris
>
>
> Chris Campbell
>
> Tel. +44 (0) 1249 705 450 | Mobile. +44 (0) 7929 628 349
> [email protected] | http://www.mango-solutions.com Mango
> Solutions, 2 Methuen Park, Chippenham, Wiltshire, SN14 OGB UK
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Bernard Ngara
> Sent: 12 April 2013 15:49
> To: nmusers
> Subject: [NMusers] NONMEM vs WinNonlin
>
> Dear all
>
> What are the major similarities and dissimilarities between NONMEM and
> WinNonlin in modeling sparse dataset.
>
> Bernard
>
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