NONMEM $PRIOR related question

On Fri, Apr 5, 2024, 3:56 PM Santosh <[email protected]> wrote: > Hi > > Not sure if my earlier post went through, hence re-posting … > > While running a model with $PRIOR in NONMEM, is there an upper limit on > the size of variance-covariance matrix given as prior ? One of the > examples (example6) in NONMEM documentation shows up to 8x8 matrix. I am > currently using NONMEM version 7.3.0 or later. > > TIA > Santosh >

On Fri, Apr 5, 2024 at 5:28 PM Gitabhi <[email protected]> wrote: > Hi Santosh, > If I understand your question, the THETA prior variance - covariance > matrix should provide variances for THETA priors. Therefore the upper limit > of its size should equal the number of THETAs with priors. > > If the size is lower than number of THETAs with priors, then THETA priors > without specified variances become uninformative priors (i.e., large > variance is assumed). > Best. > > Eliford > > > On Fri, Apr 5, 2024, 3:56 PM Santosh <[email protected]> wrote: > >> Hi >> >> Not sure if my earlier post went through, hence re-posting … >> >> While running a model with $PRIOR in NONMEM, is there an upper limit on >> the size of variance-covariance matrix given as prior ? One of the >> examples (example6) in NONMEM documentation shows up to 8x8 matrix. I am >> currently using NONMEM version 7.3.0 or later. >> >> TIA >> Santosh >> >