Dear nmusers:
This past week we have begun shipping CD's of NONMEM 7.2.0 to all users
with up-to-date licenses.
Some of the new features of NONMEM 7.2.0 include:
Dynamic Memory Allocation: No need to modify SIZES for unusually large
problems. Memory is automatically sized according to the number of
parameters and number of subjects. User may override computer generated
values using a $SIZES statement in the control stream. Often for
moderate sized problems, this results in much smaller memory usage,
compared to the standard memory usage in NONMEM 7.1. Particularly
helpful for parallel computing when using multiple cores on a single
computer.
Parallel Computing: The computation of a single problem that can take
many hours or days may be distributed over two or more cores and/or
computers to complete in a shorter time.
MSF file system: Fully expanded to Monte Carlo Methods: Seamless
resumption of expectation-maximization and Bayesian methods in case of
sudden interruption, since the last print iteration.
XML Formatted Output: An XML markup version of the standard results
output file is automatically produced.
Control Stream Files may be written in mixed case
Stochastic Differential Equations (SDE): Additional data items have
been added to facilitate SDE problems. In addition, a plug in routine
("OTHER=sde.f90") is available for Monte Carlo methods (but not for FOCE
methods), that evaluates the stochastic differential equations, without
requiring coding of these equations in the control stream file by the
user.
A new version of NONMEM Users Guide - Part V Introductory Guide, dated
April 2011,is distributed with NONMEM 7.2. This is the first update
since 1994. It can be found in the guides directory as v.pdf. The help
and html directories have also been updated for NONMEM 7.2. In
addition, several bugs have been fixed that were in NONMEM 7.1.2.
The companion graphical interface to NONMEM 7.2.0, PDx-Pop 5.0, will be
available shortly for download from the ICON ftp site
ftp://nonmem.iconplc.com/Public. It features full compatibility with
NONMEM 7.2.0 including parallel computing and a graphical NONMEM
installer for NONMEM 7.x. A "parafile Wizard" is included to automate
preparation of the file required for file passing or Message Passing
Interface (MPI) parallel computing. Other recent additions to PDx-Pop
include post-processing of runs to allow use of PDx-Pop graphical,
statistic and model evaluation methods (from runs not initiated by
PDx-Pop), run-time plotting of any model parameter, summary files for
multiple estimation method runs. PDx-Pop 5.0 will also be distributed
as a CD-ROM to current PDx-Pop customers.
If you do not receive your NONMEM 7.2.0 CD by May 31 , or if you wish
to update your license to receive a copy, please contact
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com <outbind://63/www.icondevsolutions.com>