Hello The NONMEM Professionals,
The model requires SAEM. Is mu coding useful when each subject has to have different SD (SDi=SD0*exp(etai))?
It may look something like
MU_8 =THETA(8)
SD = DEXP(MU_8 +ETA(8))
$THETA (0.00001,0.0413,50) ;SD1
$THETA (0.001 FIX) ;SD2
GRD=TG(1-9) ;(instead of GRD=TG(1-7):TS(8-9))
Thanks!
Pavel
mu coding for variability in SD
If your theta=SD’s will have etas, no need for TS() specification. You should
not need to put in the GRD statement at all, then. (The TG() is to force Gibbs
sampling in BAYES methods)
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Pavel Belo
Sent: Friday, November 20, 2015 12:31 PM
To: [email protected]
Subject: [NMusers] mu coding for variability in SD
Hello The NONMEM Professionals,
The model requires SAEM. Is mu coding useful when each subject has to have
different SD (SDi=SD0*exp(etai))?
It may look something like
MU_8 =THETA(8)
SD = DEXP(MU_8 +ETA(8))
$THETA (0.00001,0.0413,50) ;SD1
$THETA (0.001 FIX) ;SD2
GRD=TG(1-9) ;(instead of GRD=TG(1-7):TS(8-9))
Thanks!
Pavel