Modeling capacity limited PD response

From: [email protected] [mailto:[email protected]] On Behalf Of Bilal Abuasal Sent: Thursday, August 23, 2012 10:59 AM To: [email protected] Subject: [NMusers] Modeling capacity limited PD response Hi: I'm trying to develop a pop PK/PD model for a drug X that induces the secretion of the hormone Y, we are using IV infusion of X to reach the steady state, hormone Y secretion is stimulated initially by X infusion, however after 30 minutes no more Y hormone is secreted and Y levels start to decrease, which might be attributed to saturating the excretion of Y by the gland (No more hormone left in the gland). Can any one share with me a code or a modeling idea to model a scenario like that? or at least refer some article to read. Abuasal This electronic transmission may contain confidential and/or proprietary information and is intended to be for the use of the individual or entity named above. If you are not the intended recipient, be aware that any disclosure, copying, distribution or use of the contents of this electronic transmission is prohibited. If you have received this electronic transmission in error, please destroy it and immediately notify us of the error. Thank you.

________________________________________ From: [email protected] [[email protected]] on behalf of Lavigne, Jean [[email protected]] Sent: 23 August 2012 17:20 To: Bilal Abuasal; [email protected] Subject: RE: [NMusers] Modeling capacity limited PD response Dear Abusal, The first things that come to my mind is an indirect response with stimulation of the Kout to model your hormone Y. See paper Integrated Functions for Four Basic Models of Indirect Pharmacodynamic Response from WOJCIECH KRZYZANSKI AND WILLIAM J. JUSKO at the following link for more information on this type of model: http://www.pharmanet.com.br/pdf/js970168r.pdf. Jean From: [email protected] [mailto:[email protected]] On Behalf Of Bilal Abuasal Sent: Thursday, August 23, 2012 10:59 AM To: [email protected] Subject: [NMusers] Modeling capacity limited PD response Hi: I'm trying to develop a pop PK/PD model for a drug X that induces the secretion of the hormone Y, we are using IV infusion of X to reach the steady state, hormone Y secretion is stimulated initially by X infusion, however after 30 minutes no more Y hormone is secreted and Y levels start to decrease, which might be attributed to saturating the excretion of Y by the gland (No more hormone left in the gland). Can any one share with me a code or a modeling idea to model a scenario like that? or at least refer some article to read. Abuasal This electronic transmission may contain confidential and/or proprietary information and is intended to be for the use of the individual or entity named above. If you are not the intended recipient, be aware that any disclosure, copying, distribution or use of the contents of this electronic transmission is prohibited. If you have received this electronic transmission in error, please destroy it and immediately notify us of the error. Thank you.