RE: Modeling capacity limited PD response
Dear Abusal,
The first things that come to my mind is an indirect response with stimulation
of the Kout to model your hormone Y.
See paper Integrated Functions for Four Basic Models of Indirect
Pharmacodynamic Response from WOJCIECH KRZYZANSKI AND WILLIAM J. JUSKO at the
following link for more information on this type of model:
http://www.pharmanet.com.br/pdf/js970168r.pdf.
Jean
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Bilal Abuasal
Sent: Thursday, August 23, 2012 10:59 AM
To: [email protected]
Subject: [NMusers] Modeling capacity limited PD response
Hi:
I'm trying to develop a pop PK/PD model for a drug X that induces the secretion
of the hormone Y,
we are using IV infusion of X to reach the steady state, hormone Y secretion
is stimulated initially by X infusion, however after 30 minutes no more Y
hormone is secreted and Y levels start to decrease, which might be attributed
to saturating the excretion of Y by the gland (No more hormone left in the
gland).
Can any one share with me a code or a modeling idea to model a scenario like
that?
or at least refer some article to read.
Abuasal
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