Hello NONMEM users,
We (Nicola Melillo and Hitesh Mistry) would like to introduce a Shiny PBPK app
entitled, "Manchester PBPK", which can be used for exploring mean bottom up PK
simulations in different species. The code is kept simple and it is open-source
( https://github.com/NicolaMelillo/ManchesterPBPK), so that one can easily view
all the equations and how they link together to generate concentration
time-profiles in different organs. It can be used for teaching but also to
simply explore a new compound for which only in-vitro data is available.
The code/model will be further developed based on feedback we receive over
time. If others want to edit/develop aspects please feel free to do so.
Enjoy,
Hitesh Mistry (Division of Pharmacy, Division of Cancer Sciences, University of
Manchester)
Nicola Melillo (ex-Division of Pharmacy, University of Manchester)
Manchester PBPK
P.S.
Its online too: https://manchester.shinyapps.io/pbpk/ It can handle 50
concurrent users and will timeout after 1 hour of inactivity.
Quoted reply history
________________________________
From: Hitesh Mistry
Sent: Monday, August 2, 2021 2:53 PM
To: [email protected] <[email protected]>
Subject: Manchester PBPK
Hello NONMEM users,
We (Nicola Melillo and Hitesh Mistry) would like to introduce a Shiny PBPK app
entitled, "Manchester PBPK", which can be used for exploring mean bottom up PK
simulations in different species. The code is kept simple and it is open-source
( https://github.com/NicolaMelillo/ManchesterPBPK), so that one can easily view
all the equations and how they link together to generate concentration
time-profiles in different organs. It can be used for teaching but also to
simply explore a new compound for which only in-vitro data is available.
The code/model will be further developed based on feedback we receive over
time. If others want to edit/develop aspects please feel free to do so.
Enjoy,
Hitesh Mistry (Division of Pharmacy, Division of Cancer Sciences, University of
Manchester)
Nicola Melillo (ex-Division of Pharmacy, University of Manchester)