Manchester PBPK

Hello NONMEM users, We (Nicola Melillo and Hitesh Mistry) would like to introduce a Shiny PBPK app entitled, "Manchester PBPK", which can be used for exploring mean bottom up PK simulations in different species. The code is kept simple and it is open-source ( https://github.com/NicolaMelillo/ManchesterPBPK), so that one can easily view all the equations and how they link together to generate concentration time-profiles in different organs. It can be used for teaching but also to simply explore a new compound for which only in-vitro data is available. The code/model will be further developed based on feedback we receive over time. If others want to edit/develop aspects please feel free to do so. Enjoy, Hitesh Mistry (Division of Pharmacy, Division of Cancer Sciences, University of Manchester) Nicola Melillo (ex-Division of Pharmacy, University of Manchester)