Hello,
I would like to model some data for both IV and SC injection simultaneously to
estimate F1. The first order absorption for SC does not fit well and I would
like to try to fit with zero order absorption. I would like to know if this
code is correct in order to do this. I have both IV and SC dosed in the dataset
into CMT =1 for IV RATE=0 for SC RATE= -2.
Thanks,
Justus
$PK
TVCL = THETA(1)
TVV = THETA(2)
TVDUR = THETA(3)
CL = TVCL*EXP(ETA(1))
V = TVV*EXP(ETA(2))
D1 = TVDUR*EXP(ETA(3))
F1= THETA(4)
IV and SC injection
Justus
This looks OK except you need to assign F1=1 for IV, so it should be
F1=1
IF(ROUT.EQ.SC) F1=THETA(4)
where ROUT is a covariate that is equal to SC for SC administration subjects or doses.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Quoted reply history
On 10/17/2013 4:15 AM, Justus Bingham wrote:
> Hello,
>
> I would like to model some data for both IV and SC injection simultaneously to
> estimate F1. The first order absorption for SC does not fit well and I would
> like to try to fit with zero order absorption. I would like to know if this
> code is correct in order to do this. I have both IV and SC dosed in the dataset
> into CMT =1 for IV RATE=0 for SC RATE= -2.
>
> Thanks,
>
> Justus
>
> $PK
>
> TVCL = THETA(1)
> TVV = THETA(2)
> TVDUR = THETA(3)
>
> CL = TVCL*EXP(ETA(1))
> V = TVV*EXP(ETA(2))
> D1 = TVDUR*EXP(ETA(3))
>
> F1= THETA(4)