Implementation of the OMEGA covariance matrix

4 messages 4 people Latest: Aug 14, 2015

Implementation of the OMEGA covariance matrix

From: Ana Miranda Bastos Date: July 28, 2015 technical
Dear NMusers, I wonder if someone could help me to implement the OMEGA covariance matrix below. $OMEGA 0.09 ; PPV_VMAX 0.00 0.09 ; PPV_V1 0.00 0.00 0.09 ; PPV_V2 0.00 0.00 0.00 0.09 ; PPV_KD 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM I don't want to fix any value to zero, but I don't know how to better illustrate that I would like to consider a covariance between: . V1 and Bmax . Bmax and Km . V1 and Km Any advice is highly appreciated. Thank you in advance. Kind regards, Ana ------------------------------------------ Ana Bastos, Pharm, MSc, PhD student Pharmacologie cellulaire et moléculaire (Cellular and Molecular Pharmacology Unit) Louvain Drug Research Institute Université catholique de Louvain (Catholic University of Louvain) UCL 7370 avenue E. Mounier 73 1200 Bruxelles, Belgique ------------------------------------------ http://www.facm.ucl.ac.be

RE: Implementation of the OMEGA covariance matrix

From: Rudy Gunawan Date: July 28, 2015 technical
Hi Ana, What you can do is rearrange your ETA order, ie, the full block and the rest as with a separate '$OMEGA' $OMEGA BLOCK(3) 0.09 ; V1 0.01 0.09 ;BMAX 0.01 0.01 0.09 ;KM $OMEGA ... Hope this helps, Rudy
Quoted reply history
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Ana Miranda Bastos Sent: Tuesday, July 28, 2015 5:52 AM To: [email protected] Subject: [NMusers] Implementation of the OMEGA covariance matrix Dear NMusers, I wonder if someone could help me to implement the OMEGA covariance matrix below. $OMEGA 0.09 ; PPV_VMAX 0.00 0.09 ; PPV_V1 0.00 0.00 0.09 ; PPV_V2 0.00 0.00 0.00 0.09 ; PPV_KD 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM I don't want to fix any value to zero, but I don't know how to better illustrate that I would like to consider a covariance between: . V1 and Bmax . Bmax and Km . V1 and Km Any advice is highly appreciated. Thank you in advance. Kind regards, Ana ------------------------------------------ Ana Bastos, Pharm, MSc, PhD student Pharmacologie cellulaire et moléculaire (Cellular and Molecular Pharmacology Unit) Louvain Drug Research Institute Université catholique de Louvain (Catholic University of Louvain) UCL 7370 avenue E. Mounier 73 1200 Bruxelles, Belgique ------------------------------------------ http://www.facm.ucl.ac.be

RE: Implementation of the OMEGA covariance matrix

From: Elke Krekels Date: July 28, 2015 technical
Dear Ana, If you only want to consider covariance between 3 parameters, I suggest you put these three in an $OMEGA BLOCK(3) and list the remaining OMEGAs separately outside the block. Best, Elke
Quoted reply history
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Ana Miranda Bastos Sent: Tuesday, July 28, 2015 2:52 PM To: [email protected] Subject: [NMusers] Implementation of the OMEGA covariance matrix Dear NMusers, I wonder if someone could help me to implement the OMEGA covariance matrix below. $OMEGA 0.09 ; PPV_VMAX 0.00 0.09 ; PPV_V1 0.00 0.00 0.09 ; PPV_V2 0.00 0.00 0.00 0.09 ; PPV_KD 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM I don't want to fix any value to zero, but I don't know how to better illustrate that I would like to consider a covariance between: . V1 and Bmax . Bmax and Km . V1 and Km Any advice is highly appreciated. Thank you in advance. Kind regards, Ana ------------------------------------------ Ana Bastos, Pharm, MSc, PhD student Pharmacologie cellulaire et moléculaire (Cellular and Molecular Pharmacology Unit) Louvain Drug Research Institute Université catholique de Louvain (Catholic University of Louvain) UCL 7370 avenue E. Mounier 73 1200 Bruxelles, Belgique ------------------------------------------ http://www.facm.ucl.ac.be

Re: Implementation of the OMEGA covariance matrix

From: Rong Chen Date: August 14, 2015 technical
Dear Ana, I think the matrix presented in your email is already able to realize your idea if you change '$OMEGA' to '$OMEGA BLOCK(6)'.A value of 0 in OMEGA matrix is considered as it's fixed to this value. Personall speaking, I suggest you take Elke/Rudy's advice, putting these three in an $OMEGA BLOCK(3) and list the remaining OMEGAs separately in$OMEGA. But technically, they are all the same, because the default assumption in $OMEGA is that they are diagonal matrices with all off-diagonal elements assumed to be 0. Best regards,Rong
Quoted reply history
From: Ana Miranda Bastos <[email protected]> To: "[email protected]" <[email protected]> Sent: Tuesday, 28 July 2015, 20:52 Subject: [NMusers] Implementation of the OMEGA covariance matrix Dear NMusers, I wonder if someone could help me to implement the OMEGA covariance matrix below. $OMEGA 0.09 ; PPV_VMAX 0.00 0.09 ; PPV_V1 0.00 0.00 0.09 ; PPV_V2 0.00 0.00 0.00 0.09 ; PPV_KD 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM I don't want to fix any value to zero, but I don't know how to better illustrate that I would like to consider a covariance between: . V1 and Bmax . Bmax and Km . V1 and Km Any advice is highly appreciated. Thank you in advance. Kind regards, Ana ------------------------------------------ Ana Bastos, Pharm, MSc, PhD student Pharmacologie cellulaire et moléculaire (Cellular and Molecular Pharmacology Unit) Louvain Drug Research Institute Université catholique de Louvain (Catholic University of Louvain) UCL 7370 avenue E. Mounier 73 1200 Bruxelles, Belgique ------------------------------------------ http://www.facm.ucl.ac.be