Galadriel,
could you turn the dose compartment off with an other event (EVID = 2, CMT = -1), then given another dose after that. ; E.G, with emesis at four hours:
#ID TIME CMT AMT EVID IND
1 0 1 100 1 1
1 4 -1 . 2 0 1 4 1 100 1 2
$PK
; IF(IND.EQ.1) THEN
F1 = THETA(1) ; FRACTION NOT LOST
ALAG1 = THETA(2) ; NORMAL LAG
ELSE
F1 = (1-THETA(1))*THETA(3) ; THETA(3) IS REDUCED BIOAVAILABILITY
ALAG1 = THETA(4) ; LAG AFTER EMESIS
END IF
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
When CMT is 0, no change is made in the status of any compart-
ment.
PCMT is the same as for dose events.
Mark (aka Golum)
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185
Quoted reply history
-------- Original Message --------
Subject: [NMusers] How to code vomit event as absorption lag and lost
of amount in administration comp.
From: Galadriel <wyxiong Date: Tue, July 22, 2008 7:13 am
To:
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