Dear NMUsers
We are investigating the purchase of a hyperthreaded dual quad-core machine (8
physical cores; hyperthreaded to create 16 logical cores) with a view to
reducing the time taken for those aspects of model validation that require
multiple iterations e.g. bootstrapping, likelihood profiling. Our current
system uses NONMEM 7, with Intel Fortran running under Windows XP Professional,
32 bit machine . A licensed version of PLT Tools is used for graphical output
and to facilitate model development and validation.
We are wondering whether a 64bit operating system would be preferred for
optimal performance e.g. 64bit Windows 7? Any comments or recommendations
gratefully received.
With thanks and best wishes
Ann
_______________________________________________________________________
Ann Rigby-Jones PhD MRSC
Research Fellow in Pharmacokinetics & Pharmacodynamics
Peninsula College of Medicine & Dentistry
N31, ITTC Phase 1
Tamar Science Park
1 Davy Road
Derriford
Plymouth
PL6 8BX
_______________________________________________________________________
High spec PC setup for NONMEM - recommendations?
Ann, We benchmarked 32 bit vs 64 bit Intel fortran with NONMEM a few years ago, with 64 bit XP - the 64 bit version was 10-20% faster. NONMEM does not multithread (although the next version will multi process). IMHO, you get the most for your money with an quad core Intel i5, it is essentially as fast as the I7, but without multithreading. In our benchmarks, NONMEM performance correlated well with SPECfp benchmark ( www.spec.org ). I'd suggest staying away from AMD CPUs, the latest ones are advertised as 12 core, and they are, they have 12 integer computational units, but have only 6 floating point units, and they perform less well than i5s. BTW, if you can wait, the Intel 8 core CPUs are supposed to be out 3rd quarter. Mark Mark Sale MD President, Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 A carbon-neutral company See our real time solar energy production at: http://enlighten.enphaseenergy.com/public/systems/aSDz2458
Quoted reply history
-------- Original Message --------
Subject: [NMusers] High spec PC setup for NONMEM - recommendations?
From: Ann Rigby-Jones < [email protected] >
Date: Wed, January 26, 2011 9:42 am
To: " [email protected] " < [email protected] >
Dear NMUsers We are investigating the purchase of a hyperthreaded dual quad-core machine (8 physical cores; hyperthreaded to create 16 logical cores) with a view to reducing the time taken for those aspects of model validation that require multiple iterations e.g. bootstrapping, likelihood profiling. Our current system uses NONMEM 7, with Intel Fortran running under Windows XP Professional, 32 bit machine . A licensed version of PLT Tools is used for graphical output and to facilitate model development and validation. We are wondering whether a 64bit operating system would be preferred for optimal performance e.g. 64bit Windows 7? Any comments or recommendations gratefully received. With thanks and best wishes Ann _______________________________________________________________________ Ann Rigby-Jones PhD MRSC Research Fellow in Pharmacokinetics & Pharmacodynamics Peninsula College of Medicine & Dentistry N31, ITTC Phase 1 Tamar Science Park 1 Davy Road Derriford Plymouth PL6 8BX _______________________________________________________________________
Hello Ann,
We have 64 bit laptop and 32 bit server. Processors have similar speed. It
takes about the same time to run jobs.
I do not know what will happen when we get the next version of NONMEM.
Take care,
Pavel
Quoted reply history
----- Original Message -----
From: Ann Rigby-Jones
Date: Wednesday, January 26, 2011 10:12 am
Subject: [NMusers] High spec PC setup for NONMEM - recommendations?
To: "[email protected]"
> Dear NMUsers
>
> We are investigating the purchase of a hyperthreaded dual quad-
> core machine (8 physical cores; hyperthreaded to create 16
> logical cores) with a view to reducing the time taken for those
> aspects of model validation that require multiple iterations
> e.g. bootstrapping, likelihood profiling. Our current system
> uses NONMEM 7, with Intel Fortran running under Windows XP
> Professional, 32 bit machine . A licensed version of PLT Tools
> is used for graphical output and to facilitate model development
> and validation.
>
> We are wondering whether a 64bit operating system would be
> preferred for optimal performance e.g. 64bit Windows 7? Any
> comments or recommendations gratefully received.
>
> With thanks and best wishes
>
> Ann
> _______________________________________________________________________
> Ann Rigby-Jones PhD MRSC
> Research Fellow in Pharmacokinetics & Pharmacodynamics
> Peninsula College of Medicine & Dentistry
>
> N31, ITTC Phase 1
> Tamar Science Park
> 1 Davy Road
> Derriford
> Plymouth
> PL6 8BX
>
> _______________________________________________________________________
>
>
>
Ann,
RAM could be a problem if you like to run 16 jobs at once. If so, you may need a 64-bit machine to support more than 4 Gb of RAM.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Quoted reply history
On 1/26/2011 10:40 AM, Mark Sale - Next Level Solutions wrote:
> Ann,
> We benchmarked 32 bit vs 64 bit Intel fortran with NONMEM a few years
> ago, with 64 bit XP - the 64 bit version was 10-20% faster.
> NONMEM does not multithread (although the next version will multi
> process). IMHO, you get the most for your money with an quad core Intel
> i5, it is essentially as fast as the I7, but without multithreading. In
> our benchmarks, NONMEM performance correlated well with SPECfp benchmark
> (www.spec.org http://www.spec.org).
> I'd suggest staying away from AMD CPUs, the latest ones are advertised
> as 12 core, and they are, they have 12 integer computational units, but
> have only 6 floating point units, and they perform less well than i5s.
> BTW, if you can wait, the Intel 8 core CPUs are supposed to be out 3rd
> quarter.
>
> Mark
>
> Mark Sale MD
> President, Next Level Solutions, LLC
> www.NextLevelSolns.com http://www.NextLevelSolns.com
> 919-846-9185
> A carbon-neutral company
> See our real time solar energy production at:
> http://enlighten.enphaseenergy.com/public/systems/aSDz2458
>
> -------- Original Message --------
> Subject: [NMusers] High spec PC setup for NONMEM - recommendations?
> From: Ann Rigby-Jones <[email protected]
> <mailto:[email protected]>>
> Date: Wed, January 26, 2011 9:42 am
> To: "[email protected] <mailto:[email protected]>"
> <[email protected] <mailto:[email protected]>>
>
> Dear NMUsers
> We are investigating the purchase of a hyperthreaded dual quad-core
> machine (8 physical cores; hyperthreaded to create 16 logical cores)
> with a view to reducing the time taken for those aspects of model
> validation that require multiple iterations e.g. bootstrapping,
> likelihood profiling. Our current system uses NONMEM 7, with Intel
> Fortran running under Windows XP Professional, 32 bit machine . A
> licensed version of PLT Tools is used for graphical output and to
> facilitate model development and validation.
> We are wondering whether a 64bit operating system would be preferred
> for optimal performance e.g. 64bit Windows 7? Any comments or
> recommendations gratefully received.
> With thanks and best wishes
> Ann
> _______________________________________________________________________
> *Ann Rigby-Jones PhD MRSC*
> Research Fellow in Pharmacokinetics & Pharmacodynamics
> Peninsula College of Medicine & Dentistry
> N31, ITTC Phase 1
> Tamar Science Park
> 1 Davy Road
> Derriford
> Plymouth
> PL6 8BX
>
> _______________________________________________________________________