Dear nmusers:
There are several example problems that have been recently posted at
https://nonmem.iconplc.com/nonmem/
that may be helpful to you. Please read the readme documents to these folders.
Bivariate
These examples are from working with Matt Hutmacher, and describe how one can
model multi-level category problems and incorporate correlations between
adjacent data points in a systematic manner using the normal bivariate normal
cumulative distribution function.
hmm
These examples are from working with Elodie Plan, demonstrating how to build
hidden Markov models in NONMEM, for Laplace, IMP, and SAEM.
In addition, various utilities for processing NONMEM input and output files are
available at
https://nonmem.iconplc.com/utilities/
Please read readme_utilities.pdf for information on these utilities.
Of particular note, the file scm.zip in the utilities folder contains the
utility objmap than can be used to organize results of a series of stepwise
covariate model (scm) building problems, map out various relationships and
catalogue their p-values. Please read objmap.pdf in scm.zip. Also, objmap can
be used as a companion to PsN's scm program, and an example is given in the
subfolder scm, within folder objmap.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com/