From:Leijun Hu hu.105@osu.edu
Subject: [NMusers] error message: Number of evaluations of differential equations
Date: Mon, April 19, 2004 1:09 pm
Hi all,
I am trying to fit a hybrid PBPK model with NONMEM. The issue I got is that
it repeatedly came up with the error message: NUMERICAL DIFFICULTIES WITH
INTEGRATION ROUTINE. MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS,
100000, EXCEEDED. I have read earlier discussions regarding this issue and tried to
put verbatim code (from http://www.cognigencorp.com/nonmem/nm/98oct071998.html)
in the $PK block. Unfortunately, every time I tried to run it, there
was a new error message:
FSUBS.for<78>: Error: Syntax error, found '**' when expecting one of:
< * <IDENTIFIER> <CHAR_CON_KIND_PARAM> <CHAR_NAM_KIND_PARAM> <CHARACTER_CONSTANT>...
DIMENSION COM<****>
----------------------------^
FSUBS.for<9>: Error: This EQUIVALENCE object must be an array. [COM]
EQUIVALENCE<TVFAST,COM<1>>
---------------------------------------------^
Does anyone have an idea what this is about? Actually, by fixing some of the
parameters to be fit, I was able to run my model, but the fitting result was
kinda skewed. So..., I would still like to use a higher IMAX number and fit
all the parameters together. BTW, I have compaq fortran 6.6b. Just wonder
if this is related to the newer fortran version.
Many thanks.
Leijun
error message: Number of evaluations of differential equations
From: Bachman, William (MYD) bachmanw@iconus.com
Subject: RE:[NMusers] error message: Number of evaluations of differential equations
Date: Mon, April 19, 2004 3:19 pm
This same problem was discussed one week ago by Nick Holford and
Matt Hutmacher (99apr082004.html),
the suggested fix was(98apr192004.html):
> > Try the following code changes to NMTRAN subroutine GENCOM.for after
> > copying the original file to GENCOM.save.
> >
> > After the line
> > CHARACTER*12 WORK
> > add the line
> > CHARACTER*13 WORKX
> >
> > Edit the line
> > WRITE (WORK,'(A,I4.4,A)') 'BBBBBB(',I,')'
> > to be
> > WRITE (WORKX,'(A,I5.5,A)') 'BBBBBB(',I,')'
> >
> > In the IF THEN ELSE block that follows
> > edit the lines
> > LINE(LL+1:)=WORK
> > LL=LL+12
> > ELSE
> > LINE(LL+1:)=','//WORK
> > LL=LL+13
> > to be
> > LINE(LL+1:)=WORKX
> > LL=LL+13
> > ELSE
> > LINE(LL+1:)=','//WORKX
> > LL=LL+14
then delete the object files nonmem.lib in c:\nmv\nm and re-run SETUP.bat from the c:\nmv directory.
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