error message: Number of evaluations of differential equations
From:Leijun Hu hu.105@osu.edu
Subject: [NMusers] error message: Number of evaluations of differential equations
Date: Mon, April 19, 2004 1:09 pm
Hi all,
I am trying to fit a hybrid PBPK model with NONMEM. The issue I got is that
it repeatedly came up with the error message: NUMERICAL DIFFICULTIES WITH
INTEGRATION ROUTINE. MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS,
100000, EXCEEDED. I have read earlier discussions regarding this issue and tried to
put verbatim code (from http://www.cognigencorp.com/nonmem/nm/98oct071998.html)
in the $PK block. Unfortunately, every time I tried to run it, there
was a new error message:
FSUBS.for<78>: Error: Syntax error, found '**' when expecting one of:
< * <IDENTIFIER> <CHAR_CON_KIND_PARAM> <CHAR_NAM_KIND_PARAM> <CHARACTER_CONSTANT>...
DIMENSION COM<****>
----------------------------^
FSUBS.for<9>: Error: This EQUIVALENCE object must be an array. [COM]
EQUIVALENCE<TVFAST,COM<1>>
---------------------------------------------^
Does anyone have an idea what this is about? Actually, by fixing some of the
parameters to be fit, I was able to run my model, but the fitting result was
kinda skewed. So..., I would still like to use a higher IMAX number and fit
all the parameters together. BTW, I have compaq fortran 6.6b. Just wonder
if this is related to the newer fortran version.
Many thanks.
Leijun