From: Stu Beal
Subject: [NMusers] Epsilons correlated across L2 records
Date: December 3 2003
Few NONMEM analyses have used correlated epsilons across L2 records.
Regrettably though, we have now learned that the results from any previous
attempt to do this (using NONMEM-PRED common NMPRD5) *with conditional
estimation* are erroneous.
If the user wishes to use correlated epsilons across L2 records with condi-
tional estimation, then the following code change in NONMEM routine OBJ2
should be made.
LOCATE the two lines of code:
IQ=0
IF (MODE.EQ.2) THEN
REPLACE these with:
IF (MODE.NE.3) THEN
IQ=0
Once OBJ2 source code has been changed, it must be recompiled. (See Users
Guide III, p, 125 and p. 129-130, in which we suggest erasing all object
modules (.obj or .o) in the nm subdirectory and then using the SETUP com-
mand as it was originally typed.)
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Epsilons correlated across L2 records
From: "Ludden, Thomas (MYD)" luddent@iconus.com
Subject: [NMusers] Epsilons correlated across L2 records
Date: 12/4/2003 9:49 AM
Professor Stuart Beal has asked that the following message be posted to
nmusers.
Tom Ludden
GloboMax
The Strategic Pharmaceutical Development Division of ICON plc