Epsilons correlated across L2 records

From: Stu Beal Subject: [NMusers] Epsilons correlated across L2 records Date: December 3 2003 Few NONMEM analyses have used correlated epsilons across L2 records. Regrettably though, we have now learned that the results from any previous attempt to do this (using NONMEM-PRED common NMPRD5) *with conditional estimation* are erroneous. If the user wishes to use correlated epsilons across L2 records with condi- tional estimation, then the following code change in NONMEM routine OBJ2 should be made. LOCATE the two lines of code: IQ=0 IF (MODE.EQ.2) THEN REPLACE these with: IF (MODE.NE.3) THEN IQ=0 Once OBJ2 source code has been changed, it must be recompiled. (See Users Guide III, p, 125 and p. 129-130, in which we suggest erasing all object modules (.obj or .o) in the nm subdirectory and then using the SETUP com- mand as it was originally typed.) _______________________________________________________